Choices in time and neural activity in parietal cortex

时间和顶叶皮层神经活动的选择

• 批准号: 7056613
• 负责人: KENWAY LOUIE
• 金额: $ 5.04万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056613
• 关键词: Primates; choice; decision making; neurons; parietal lobe /cortex; preference; role

DESCRIPTION (provided by applicant): Decision-making is a complex process requiring the integration of both current sensory information about the world and stored knowledge about environmental contingencies. Recently, neurophysiologists have begun to identify neural activity in higher order sensory and motor brain regions that correlates with decision formation. In the lateral intraparietal area (LIP), neurons encode decision variables such as expected reward magnitude, outcome probability, and subjective desirability of choices during a visuomotor task; this information is neither sensory nor motor but guides effective decision-making. Decision studies to date, however, have ignored information about time, a crucial element of choice behavior: real world decisions occur between choices with different outcomes at different times. The goal of the proposed research is to develop a psychophysical test to quantify primate choice behavior in time, and employ this task to explore how such temporal information is represented in the activity of decision-related neurons in LIP. This research seeks to explore both the neural basis of choice in time as well as the integration of temporal information into decision processes.

描述（由申请人提供）：决策是一个复杂的过程，需要整合当前关于世界的感官信息和存储的关于环境突发事件的知识。最近，神经生理学家已经开始识别与决策形成相关的高级感觉和运动脑区域的神经活动。在外侧顶内区（LIP），神经元编码决策变量，如预期的奖励幅度，结果概率，以及在视觉任务中选择的主观愿望;这些信息既不是感官也不是运动，而是指导有效的决策。然而，迄今为止的决策研究都忽略了关于时间的信息，这是选择行为的一个关键因素：真实的世界决策发生在不同时间、不同结果的选择之间。拟议的研究的目标是开发一个心理物理测试，以量化灵长类动物的选择行为的时间，并采用此任务，以探索如何在LIP的决策相关的神经元的活动，这种时间信息表示。本研究旨在探索时间选择的神经基础以及将时间信息整合到决策过程中。