Memory dissociations and risk for AD versus VaD

AD 与 VaD 的记忆分离和风险

• 批准号: 7135640
• 负责人: ELIZABETH C LERITZ
• 金额: $ 5.15万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7135640
• 关键词: Alzheimer' s disease; behavioral /social science research tag; bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; brain mapping; cardiovascular disorder risk; cerebral ischemia /hypoxia; clinical research; dementia; diffusion magnetic resonance imaging; disease /disorder proneness /risk; human middle age (35-64); human old age (65+); human subject; magnetic resonance imaging; memory; memory disorders; multiinfarct dementia; postdoctoral investigator; psychological tests

DESCRIPTION (provided by applicant): The prevalence of Alzheimer's disease (AD) and vascular dementia (VaD) is increasing rapidly. Early detection of these disorders is critical, particularly now that significant progress has been made regarding diagnosis and treatment. The beginning stages of AD are characterized by atrophy to medial temporal lobe (MTL) structures, and consequently, episodic memory loss is a defining feature. In VaD, cognitive deficits arise from vascular damage to frontal lobe (FL) brain regions, and as a result, executive functioning deficits prevail. Current diagnostic criteria include memory loss as the primary neuropsychological symptom for both diseases. However, given the distinct cognitive and neuroanatomical characteristics, it is likely that the underlying memory disorders for AD and VaD are distinctive as well. In order to more clearly elucidate memory functioning in individuals at risk for developing AD and VaD, we propose two experiments which will investigate MTL and FL memory functioning in individuals at risk for AD and VaD. Performance on these tasks will be correlated with anatomical data gathered from sophisticated neuroimaging techniques designed to capture the underlying neuronal integrity of MTL and FL brain areas. Collectively, this data will provide invaluable clinical and theoretical contributions to the current literature on dementia risk.

描述（由申请人提供）：阿尔茨海默病（AD）和血管性痴呆（VaD）的患病率正在迅速上升。早期发现这些疾病至关重要，特别是现在在诊断和治疗方面取得了重大进展。阿尔茨海默病的初始阶段以内侧颞叶（MTL）结构萎缩为特征，因此，情景性记忆丧失是一个决定性特征。在VaD中，认知缺陷是由额叶（FL）大脑区域的血管损伤引起的，因此，执行功能缺陷普遍存在。目前的诊断标准包括记忆丧失作为这两种疾病的主要神经心理学症状。然而，考虑到不同的认知和神经解剖学特征，AD和VaD的潜在记忆障碍也可能是不同的。为了更清楚地阐明AD和VaD风险个体的记忆功能，我们提出了两个实验来研究AD和VaD风险个体的MTL和FL记忆功能。这些任务的表现将与复杂的神经成像技术收集的解剖学数据相关，这些技术旨在捕捉MTL和FL脑区域的潜在神经元完整性。总的来说，这些数据将为当前关于痴呆风险的文献提供宝贵的临床和理论贡献。