Neuroimaging and Neuropsychological Biomarkers of Vascular Risk Factors

血管危险因素的神经影像学和神经心理学生物标志物

• 批准号: 8817058
• 负责人: ELIZABETH C LERITZ
• 金额: $ 37.33万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8817058
• 关键词: Adult; Affect; Attention; Behavioral; Biological Markers; Biological Neural Networks; Blood Pressure; Blood Vessels; Brain; Carbon Dioxide; Cerebrovascular Disorders; Cholesterol; Clinical; Cognition; Cognition Disorders; Cognitive; Comorbidity; Complex; Corpus Callosum; Data; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Dorsal; Event; Glucose; Health; Hypertension; Impaired cognition; Individual; Intervention; Knowledge; Measurement; Measures; Medical; Metabolic syndrome; Moods; Nerve Degeneration; Neurologic; Neurologic Symptoms; Obesity; Performance; Predisposition; Prevalence; Procedures; Public Health; Research; Rest; Risk; Risk Factors; Stroke; System; Thick; Tissues; Vascular Cognitive Impairment; Vascular Dementia; Visual; brain tissue; cerebrovascular; clinical Diagnosis; clinically significant; cognitive function; design; executive function; functional status; indexing; meetings; middle age; neuroimaging; neuromechanism; neuropsychological; novel; prevent; public health relevance; relating to nervous system; white matter

DESCRIPTION (provided by applicant): Risk factors for cerebrovascular disease, such as hypertension, obesity, and diabetes, rarely occur in isolation. The clustering of three or more vascular risk factors comprises a clinical diagnosis of cardio-metabolic syndrome (CMS). In recent years, the prevalence of CMS has risen dramatically, with recent estimates of nearly 34% of US adults meeting criteria. A diagnosis of CMS in midlife, even prior to the development of clinically significant neurologic symptoms, is associated with a substantially increased risk for vascular-related neurodegenerative conditions, including vascular cognitive impairment, dementia, as well as major neurologic events such as stroke. While there is a great deal of research examining the negative impact of individual factors, such as blood pressure, on brain tissue, there is still little knowledge of the neural mechanisms underlying CMS-related changes to neural health. The current project seeks to better understand how multiple co-occurring risk factors affect vascular and neural integrity, and how cognitive and functional status is subsequently impacted. We will identify noninvasive neuroimaging, cognitive and functional biomarkers of CMS that can be used in detecting who may be at greater risk for cognitive decline and dementia. This will be accomplished with three Aims that include 1) understanding how CMS impacts specific structural and functional brain networks, 2) understanding how an index of vascular integrity, cerebrovascular reserve (CVR), impacts structural and functional brain networks in CMS, and 3) understanding how CVR interacts with structural and functional brain integrity to affect cognitive, psychiatric, and functional status. Ultimately, this project ams to provide important translational data that can be used in clinical settings for the treatment and management of multiple vascular risk factors.

描述(申请人提供)：脑血管疾病的危险因素，如高血压、肥胖和糖尿病，很少单独发生。三个或三个以上血管危险因素的聚集构成了心脏代谢综合征(CMS)的临床诊断。近年来，CMS的患病率急剧上升，最近估计有近34%的美国成年人符合标准。在中年被诊断为CMS，甚至在出现临床上显著的神经症状之前，就与血管相关的神经退行性疾病的风险显著增加有关，包括血管认知障碍、痴呆症以及中风等重大神经事件。虽然已经有大量研究探讨了血压等个体因素对脑组织的负面影响，但对于CMS相关神经健康变化背后的神经机制仍知之甚少。目前的项目试图更好地了解多种共存的风险因素如何影响血管和神经的完整性，以及认知和功能状态随后是如何受到影响的。我们将确定CMS的非侵入性神经成像、认知和功能生物标记物，这些标记物可以用于检测谁可能有更高的认知能力下降和痴呆风险。这将通过三个目标来实现，包括1)了解CMS如何影响特定的结构和功能大脑网络，2)了解血管完整性指标脑血管储备(CVR)如何影响CMS的结构和功能大脑网络，以及3)了解CVR如何与结构和功能大脑完整性相互作用，影响认知、精神和功能状态。最终，该项目旨在提供重要的翻译数据，可用于临床环境中的治疗和 多种血管危险因素的管理。