Hippocampal Involvement in Explicit and Implicit Memory

描述（由申请人提供）：多年来，记忆研究一直是 关注显性和隐性之间的理论和功能区别， 内隐记忆神经功能受损人群的表现 记忆的直接和间接测量因特定的 实验范式，使用的任务类型，以及参与过程中的具体过程 研究和测试阶段。一个理论上的问题是， 文献关注的是外显记忆和内隐记忆是否可以类似地依赖于 海马体和周围的内侧颞叶等结构， 某些类型的内隐记忆。虽然研究结果在很大程度上表明， 由于预先存在的信息与这些区域无关，因此结果非常 对于新的记忆， 表示。到目前为止，大多数结论都是基于 对健忘症患者的研究不同程度的严重性和发病部位 研究中的损害使得很难做出准确的陈述 海马体在内隐记忆中的作用现时的建议 将通过应用明确的和 颞叶癫痫患者内隐记忆范式研究 癫痫（TLE）患者有明确的内侧颞叶病变。 具体来说，我们将调查TLE患者的能力，以显示明确的 以及对新项目特定和关联信息的内隐记忆。 这些指标的表现将与可用的解剖数据相关 包括海马体积和子域细胞计数这项研究将 有助于进一步阐明海马在介导外显 和内隐记忆

DESCRIPTION (provided by applicant): For years, memory research has been concerned with theoretical and functional distinctions between explicit and implicit memory. The performance of neurologically-impaired populations on direct and indirect measures of memory has varied depending on the particular experimental paradigm, type of task used, and specific processes engaged during both study and test phases. One theoretical question that has been raised in the literature concerns whether explicit and implicit memory may rely similarly on structures such as the hippocampus and surrounding medial temporal lobe for certain types of implicit memory. While findings largely suggest that priming for preexisting information is independent of such regions, results are much more inconsistent with regard to implicit memory for novel memory representations. To this point, the majority of conclusions have been based on research in patients with amnesia. The varying degrees of severity and locus of damage across studies have made it difficult to make precise statements regarding the role of the hippocampus in implicit memory. The current proposal will provide additional data on this issue through application of explicit and implicit memory paradigms to a population of patients with temporal lobe epilepsy (TLE) who have well-defined medial temporal lobe lesions. Specifically, we will investigate the ability of TLE patients to show explicit and implicit memory for novel item specific and associative information. Performance on these measures will be correlated with available anatomic data that includes hippocampal volumes and subfield cell counts. This research will serve to further elucidate the role of the hippocampus in mediating explicit and implicit memory.