Meningioma: Risk Factors and Quality of Life

描述（由申请人提供）：颅内脑膜瘤占所有原发性颅内肿瘤的25%，但在美国尚无大规模研究调查颅内脑膜瘤流行病学的任何方面。我们建议在综合R01机制下，在康涅狄格州、马萨诸塞州、北卡罗来纳州和德克萨斯州以及旧金山湾区开展一项基于人群的脑膜瘤病例/对照研究（注意，所有五个地点都提交了相同的申请）。病例将通过快速病例确定来选择，并将包括从2006年7月1日至2010年6月30日在上述列出的地区中年龄在20至79岁之间诊断为组织学证实的颅内脑膜瘤的所有男性和女性个体。对照受试者将通过随机数字拨号方法进行识别，并按性别、种族、地理位置和5岁年龄组与病例相匹配。研究对象将接受电话问卷调查，以收集关于两类主要风险的信息，电离辐射和激素暴露，以及其他风险因素，如脑膜瘤和其他肿瘤的家族史，手机使用，头部创伤，以及关于结果和生活质量的问题。将为病例受试者获得石蜡包埋的肿瘤组织块，以便进行1)统一的组织学检查，以及2)雌激素、孕激素、雄激素和mb -1受体的免疫组织化学检测。所有研究对象将采集血液或口腔标本，用于DNA修复和细胞周期基因的DNA多态性检测。这项研究首次集中研究了脑膜瘤的环境和遗传风险因素。

DESCRIPTION (provided by applicant): No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.