Meningioma: Risk Factors and Quality of Life

=在美国没有大规模的研究对颅内脑膜瘤的流行病学进行任何方面的研究，这种病变占所有原发性颅内肿瘤的25%。我们建议在综合R 01机制下，在康涅狄格州、马萨诸塞州、北卡罗来纳州和德克萨斯州以及旧金山弗朗西斯科湾区开展一项基于人群的脑膜瘤病例/对照研究（注意，所有五个地点提交的申请相同）。将使用快速病例确定选择病例，并将包括2006年7月1日至2010年6月30日期间在上述地区诊断为20 - 79岁经组织学证实的颅内脑膜瘤的所有男性和女性个体。对照受试者将通过随机数字拨号方法识别，并按性别、种族、地理位置和5岁年龄类别与病例匹配。将对研究受试者进行电话问卷调查，以收集关于两个主要风险类别（电离辐射和激素暴露）以及其他风险因素（如脑膜瘤和其他肿瘤家族史、手机使用和头部创伤）的信息，以及关于结局和生活质量的问题。将获得病例受试者的石蜡包埋肿瘤组织块，以便1）进行统一的组织学检查，2）进行雌激素、孕激素、雄激素和MIB-1受体的免疫组织化学检测。将采集所有研究受试者的血液或口腔样本，用于检测DNA修复和细胞周期基因的DNA多态性。这项研究代表了第一次集中精力研究脑膜瘤的环境和遗传危险因素。

= No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.