Shared Resource Management

项目摘要-共享资源管理 南加州大学诺里斯综合癌症中心（NCCC）有着悠久的传统，提供创新和成本， 共享资源（SR）。NCCC管理部门在高级领导层的监督下管理所有SR 确保与NCCC战略计划保持一致并产生持续的科学影响。一组集成的 监督过程与年度核心调查相结合，促进持续改进和SR演变 以满足会员的需求。为了响应这些机制，我们已经在电流中转换了NCCC SR。 资助期，包括将生物统计学SR扩展为数据科学SR，创建新的群体 研究SR，以及NCCC成员使用相对较低的三个SR向凯克学派的过渡 医学。因此，本申请中提出的六个CCSG共享资源包括： 免疫监测核心（FCIM）、液体活检核心（LBC）、转化病理学核心（TPC）， 分子基因组学核心（MGC），数据科学核心（DSC）和人口研究核心（PRC）。我们 我还提出了一个发展中的临床前核心，为NCCC成员提供定制的临床前服务， 为赠款提案生成可靠的初步数据，并提供理由和信息， 设计新颖的早期临床试验。值得注意的是，我们对SR进行了大量投资， 我们的年度使用指标和年度核心调查证明了这一投资的强劲回报。 具体来说，187名NCCC正式成员中有168名在2019财年使用了至少一个NCCC SR（这168名成员中的80% 成员有同行评审的资金），77%的人报告说，他们对 服务要么是杰出的，要么是非常好的（前两个类别）。使用NCCC SR直接有助于 642篇文章CCSG对NCCC共享资源的预算贡献仅占SR总额的24% 本期间的业务预算，其余部分由机构资金支助， 退款或授予支持。在本赠款周期内，对NCCC工作人员代表的机构投资已经结束 520万

PROJECT SUMMARY - Shared Resource Management The USC Norris Comprehensive Cancer Center (NCCC) has a long tradition of providing innovative and cost- effective Shared Resources (SRs). NCCC Administration manages all SRs with Senior Leadership oversight to ensure alignment with the NCCC Strategic Plan and a sustained scientific impact. An integrated set of oversight processes, combined with the annual core survey, fosters continued improvement and SR evolution to meet members' needs. In response to these mechanisms, we have transformed NCCC SRs in the current grant period, including expansion of the Biostatistics SR into a Data Science SR, creation of a new Population Research SR, and transition of three SRs that had relatively lower use by NCCC members to the Keck School of Medicine. Accordingly, the six CCSG Shared Resources proposed in this application include: Flow and Immune Monitoring Core (FCIM), Liquid Biopsy Core (LBC), Translational Pathology Core (TPC), Molecular Genomics Core (MGC), Data Science Core (DSC), and Population Research Core (PRC). We also propose a developing Preclinical Core to provide NCCC members with customized preclinical services to generate robust preliminary data for grant proposals and to provide a rationale and information to inform the design of novel early phase clinical trials. Notably, we have made substantial investments in our SRs, with a strong return on this investment as exemplified in our annual usage metrics and annual core surveys. Specifically, 168 (of 187) full NCCC members utilized at least one NCCC SR in FY19 (80% of these 168 members had peer reviewed funding), and 77% reported that their satisfaction with the overall quality of the services was either outstanding or very good (top two categories). Use of NCCC SRs directly contributed to 642 publications. The CCSG budget contribution to NCCC shared resources is only 24% of the total SR operational budget over the current period, with the remainder supported by institutional funds and chargebacks or grant support. The institutional investment to NCCC SRs in the current grant cycle was over $5.2M.