Training Program in Trauma and Organ Injury

描述（由申请人提供）：创伤性损伤仍然是一个主要的 公共卫生问题，对个人和社会产生巨大影响。一个 创伤卫生保健系统的基本组成部分是基础和临床 research.然而，创伤研究的未来进展可能是 由于受过良好训练的人数持续下降， 物理科学家拟议的创伤和器官损伤培训计划 主要为外科住院医生设计， 为期两年的研究培训，重点是负责 与损伤相关的细胞功能障碍和多器官衰竭。它将 补充正在进行的创伤研究计划已经存在于 外科、细胞和分子生理学系。的目标 培训计划是提供高素质，积极的个人与 深入的知识基础和丰富的实验室经验， 促进成功的，富有成效的职业生涯在独立的学术创伤 research.培训方案的具体目标是：（1）提供 集中在三大学科之一的综合科学训练; 内分泌/代谢、器官损伤和组织修复或神经生物学;以及 (2)在调查的各个方面提供强大的培训基础 过程培训目标将强调整合生理学， 生物化学、内分泌学和神经生物学， 分子生物学成熟的研究者（临床和基础研究 科学家）在外科，细胞和分子部门 生理学、骨科、内科/心脏病学、儿科和 神经科学和解剖学将作为核心教师导师，并将 负责指导和评估学员的进步。学员将 在实验设计的各个方面接受直接监督， 技术专长和科学写作，以及参与 研究道德行为必修课。候选人将被招募 在当地和全国范围内，将作出广泛努力， 妇女和少数民族候选人进入该计划。计划毕业生将 临床科学家谁拥有足够的科学成熟度，开始一个 从事独立研究，并为 关于创伤病理生理学知识的进步。

DESCRIPTION (provided by applicant): Traumatic injury continues to be a major public health problem that impacts enormously on individuals and society. An essential component of the trauma health care system is basic and clinical research. However, future advancements in trauma research are likely to be hindered because of the continued decline in the number of well-trained physician-scientists. The proposed Training Program in Trauma and Organ Injury is designed primarily for surgical residents to provide them with an intensive two-year period of research training focused on the mechanisms responsible for the cellular dysfunction and multiorgan failure associated with injury. It will complement the ongoing trauma research programs already present in the Departments of Surgery, and Cellular and Molecular Physiology. The goal of the training program is to provide highly qualified, motivated individuals with an in-depth knowledge base and intensive laboratory experience that will facilitate successful, productive careers in independent academic trauma research. The specific aims of the training program are to: (1) provide comprehensive scientific training focused in one of three major disciplines; Endocrinology/Metabolism, Organ Injury and Tissue Repair, or Neurobiology; and (2) provide a strong training foundation in all aspects of the investigative process. The training objectives will emphasize integrating physiology, biochemistry, endocrinology, and neurobiology with techniques of cellular and molecular biology. Established investigators (both clinical and basic scientists) within the Departments of Surgery, Cellular and Molecular Physiology, Orthopedics, Internal Medicine/Cardiology, Pediatrics, and Neuroscience and Anatomy will serve as core faculty mentors, and will be responsible for directing and evaluating the trainee's progress. Trainees will receive direct supervision regarding all aspects of experimental design, technical expertise, and scientific writing as well as participate in the required course on ethical conduct in research. Candidates will be recruited both locally and nationally, and extensive efforts will be made to recruit women and minority candidates into the program. Program graduates will be clinician-scientists who possess sufficient scientific maturity to embark on a career in independent research and make significant contributions to the advancement of knowledge concerning the pathophysiology of trauma.