Training Program in Trauma and Organ Injury

描述（由申请人提供）：创伤性损伤仍然是一个重大的公共卫生问题，对个人和社会产生巨大影响。创伤卫生保健系统的一个重要组成部分是基础和临床研究。然而，由于训练有素的医生科学家数量的持续下降，创伤研究的未来进展可能会受到阻碍。这是创伤生物学和器官损伤博士后培训计划的第一个竞争性更新。培训计划主要针对外科住院医生（PGY-III和IV），为他们提供为期两年（或三年）的密集研究，重点是与损伤相关的细胞功能障碍和多器官衰竭的机制。它将补充正在进行的创伤研究计划已经存在于外科，细胞和分子生理学部门。该培训计划的目标是提供高素质，积极的个人与深入的知识基础和密集的实验室经验，将促进学术创伤研究的成功，富有成效的独立职业生涯。培训方案的具体目标是：（1）提供集中在两个主要学科之一-内分泌学和代谢以及器官损伤和组织修复-的综合科学培训;（2）在调查过程的各个方面提供坚实的培训基础。该计划的行政结构由计划主任（Wiley Souba，MD）和副主任（Charles Lang，PhD）协调。每个受训者选择共同导师（例如，一名临床科学家和一名基础科学家），他们来自外科、细胞和分子生理学、骨科、内科和药理学部门内的跨学科研究骨干，负责指导和评估受训者的进展。受训者将接受有关假设驱动的实验设计，技术专长和科学写作的各个方面的直接监督，并参加有关研究道德行为的必修课程。该计划的毕业生将是临床科学家，他们拥有足够的科学成熟度，可以从事独立研究，并为促进创伤病理生理学知识的发展做出重大贡献。

DESCRIPTION (provided by applicant): Traumatic injury continues to be a major public health problem that impacts enormously on individuals and society. An essential component of the trauma health care system is basic and clinical research. However, future advancements in trauma research are likely to be hindered because of the continued decline in the number of well-trained physician-scientists. This is the first competing renewal of a postdoctoral training program in Trauma Biology and Organ Injury. The Training Program is designed primarily for surgical residents (PGY-III and IV) to provide them with an intensive two (or three)-year period of research focused on the mechanisms responsible for the cellular dysfunction and multiorgan failure associated with injury. It will complement the ongoing trauma research programs already present in the Departments of Surgery, and Cellular and Molecular Physiology. The goal of the training program is to provide highly qualified, motivated individuals with an in-depth knowledge base and intensive laboratory experience that will facilitate a successful, productive independent career in academic trauma research. The specific aims of the training program are to: (1) provide comprehensive scientific training focused in one of two major disciplines--Endocrinology and Metabolism, and Organ Injury and Tissue Repair; and (2) provide a strong training foundation in all aspects of the investigative process. The administrative structure of the program is coordinated by the Program Director (Wiley Souba, MD) and Associate Director (Charles Lang, PhD). Each trainee selects co-mentors (e.g., one clinician-scientist and one basic scientist) from an interdisciplinary cadre of established investigators within the Departments of Surgery, Cellular and Molecular Physiology, Orthopedics, Internal Medicine, and Pharmacology which are responsible for directing and evaluating the trainee's progress. Trainees will receive direct supervision regarding all aspects of hypothesis-driven experimental design, technical expertise, and scientific writing as well as participate in the required course on ethical conduct in research. Program graduates will be clinician-scientists who possess sufficient scientific maturity to embark on a career in independent research and make significant contributions to the advancement of knowledge concerning the pathophysiology of trauma.