Training Program in Trauma and Organ Injury

描述（由申请人提供）：创伤性伤害仍然是一个重大的公共卫生问题，对个人和社会产生巨大影响。创伤卫生保健系统的一个重要组成部分是基础和临床研究。然而，由于训练有素的内科科学家数量的持续下降，未来创伤研究的进展可能会受到阻碍。这是创伤生物学和器官损伤博士后培训计划的第一个竞争性更新。培训计划主要是为外科住院医师（PGY-III和IV）设计的，为他们提供为期两年（或三年）的强化研究，重点是与损伤相关的细胞功能障碍和多器官衰竭的机制。它将补充正在进行的创伤研究项目已经存在于外科，细胞和分子生理学部门。培训计划的目标是提供具有深入知识基础和丰富实验室经验的高素质，积极进取的个人，这将有助于在学术创伤研究方面取得成功，富有成效的独立职业生涯。培训计划的具体目标是：(1)提供全面的科学培训，重点是两大学科之一-内分泌与代谢，器官损伤与组织修复；(2)在调查过程的各个方面提供强有力的培训基础。该项目的行政结构由项目主任（Wiley Souba，医学博士）和副主任（Charles Lang，博士）协调。每位受训者从外科、细胞和分子生理学、骨科、内科和药理学部门的跨学科研究骨干中选择共同导师（例如，一名临床科学家和一名基础科学家），负责指导和评估受训者的进步。学员将在假设驱动的实验设计、技术专长和科学写作的各个方面接受直接指导，并参加有关研究伦理行为的必修课程。该课程的毕业生将成为临床科学家，具备足够的科学成熟度，可以从事独立研究，并为创伤病理生理学知识的进步做出重大贡献。

DESCRIPTION (provided by applicant): Traumatic injury continues to be a major public health problem that impacts enormously on individuals and society. An essential component of the trauma health care system is basic and clinical research. However, future advancements in trauma research are likely to be hindered because of the continued decline in the number of well-trained physician-scientists. This is the first competing renewal of a postdoctoral training program in Trauma Biology and Organ Injury. The Training Program is designed primarily for surgical residents (PGY-III and IV) to provide them with an intensive two (or three)-year period of research focused on the mechanisms responsible for the cellular dysfunction and multiorgan failure associated with injury. It will complement the ongoing trauma research programs already present in the Departments of Surgery, and Cellular and Molecular Physiology. The goal of the training program is to provide highly qualified, motivated individuals with an in-depth knowledge base and intensive laboratory experience that will facilitate a successful, productive independent career in academic trauma research. The specific aims of the training program are to: (1) provide comprehensive scientific training focused in one of two major disciplines--Endocrinology and Metabolism, and Organ Injury and Tissue Repair; and (2) provide a strong training foundation in all aspects of the investigative process. The administrative structure of the program is coordinated by the Program Director (Wiley Souba, MD) and Associate Director (Charles Lang, PhD). Each trainee selects co-mentors (e.g., one clinician-scientist and one basic scientist) from an interdisciplinary cadre of established investigators within the Departments of Surgery, Cellular and Molecular Physiology, Orthopedics, Internal Medicine, and Pharmacology which are responsible for directing and evaluating the trainee's progress. Trainees will receive direct supervision regarding all aspects of hypothesis-driven experimental design, technical expertise, and scientific writing as well as participate in the required course on ethical conduct in research. Program graduates will be clinician-scientists who possess sufficient scientific maturity to embark on a career in independent research and make significant contributions to the advancement of knowledge concerning the pathophysiology of trauma.