Pediatric Neurointensive Care and Resuscitation Research

描述（由申请人提供）：儿科重症医学（PCCM）专家是神经重症监护的一线。他们应对儿科重症监护病房的危机，包括对严重创伤性脑损伤（TBI）和住院心肺骤停（CA）儿童的复苏和治疗。他们与儿童神经病学、神经外科、物理医学和康复（PM&R）专家在连续的护理中进行互动。我们独特的博士后项目培养PCCM，儿童神经病学，神经外科和PM&R研究员在神经重症监护和复苏的基础和临床研究，建立实习生与资深科学家之间的联系。在这个修订后的竞争性续期申请中，每年要求资金支持总共5个职位。该项目已经完成了第五个年头，每个职位都有高质量的研究员。3人已提交，2人获得K奖，5人已获得或正在攻读高级学位或证书。他们发表或出版了22篇同行评议论文，发表了62篇摘要，并获得了8个奖项。所有毕业生都在学术岗位。研究重点是损伤机制，新疗法，以及创伤性脑损伤和CA后的结果。我们的教师采用了由联邦资助的研究支持的从实验室到床边的方法。我们充分利用萨法尔复苏研究中心与PCCM、匹兹堡儿童医院和匹兹堡大学医学院的儿童神经病学、神经外科和PM&R培训项目之间的独特互动。主任、联合主任和主要培训师（PTs）都是敬业的、合格的科学家和经过验证的教育工作者。每个导师的研究领域提出重要问题，适合学员的职业发展和假设检验。我们还整合了神经重症监护研究课程。毕业生可以制定、执行、分析、展示和发表旨在回答关键问题的实验，并接受资助和研究诚信方面的培训。他们获得了研究未来问题的思维过程/工具。大多数培训都是通过传统的学徒制在PTs的实验室进行的。还包括儿科神经重症监护/研究方法的教学计划。每个人选择一个PT和一个专家监督小组委员会。培训在5万平方英尺内进行。1英尺的设备齐全的实验室空间。有行政/技术人员，也有临床研究的大量病例材料。平权行动招募工作已经到位。

DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine (PCCM) specialists are the front line in neurointensive care. They respond to crises in the pediatric intensive care unit, including resuscitation and treatment of children with severe traumatic brain injury (TBI) and in-hospital cardiopulmonary arrest (CA). They interact with child neurology, neurological surgery, and physical medicine and rehabilitation (PM&R) specialists in the continuum of care. Our unique postdoctoral program trains PCCM, child neurology, neurological surgery and PM&R fellows in basic and clinical research in neurointensive care and resuscitation, establishing a link between trainees and senior scientists. In this revised competitive renewal application, funds are requested to support a total of 5 positions each yr. The program is completing its 5th year and has filled every position with high-quality fellows. Three have submitted and two have acquired K awards, and 5 have acquired or are pursuing advanced degrees or certificates. They have published or in press 22 peer-reviewed papers, presented 62 abstracts, and won 8 awards. All graduates are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. A bench-to-bedside approach supported by federally funded studies by our faculty is used. We capitalize on the unique interaction between the Safar Center for Resuscitation Research and the PCCM, child neurology, neurological surgery, and PM&R training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Med. The director, co-director, and principal trainers (PTs) are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for trainee career development and hypothesis testing. We also integrate a curriculum in neurointensive care research. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions, and are trained in grantsmanship and research integrity. They acquire the thought process/tools to study future questions. Most training takes place in the labs of the PTs via a classical apprenticeship. A didactic program in pediatric neurointensive care/research methods is also included. Each fellow chooses a PT and an expert supervising subcommittee. Training is carried out in ~50,000 sq. ft. of fully equipped lab space. Administrative/technical staff is available, as is ample case material for clinical research. Affirmative action recruitment efforts are in place.