Pediatric Neurointensive Care and Resuscitation Research

描述（由申请人提供）：儿科重症监护医学（PCCM）专家是神经重症监护的第一线。他们应对儿科重症监护室的危机，包括严重创伤性脑损伤（TBI）和院内心肺骤停（CA）儿童的复苏和治疗。他们与儿童神经病学，神经外科，物理医学和康复（PM&R）专家在护理的连续性。我们独特的博士后计划培训PCCM，儿童神经病学，神经外科和PM&R研究员在神经重症监护和复苏的基础和临床研究，建立学员和高级科学家之间的联系。在此修订后的竞争性续约申请中，要求资金每年支持总共5个职位。该计划正在完成其第五个年头，并填补了高素质的研究员的每一个位置。 3人提交了K奖，2人获得K奖，5人获得或正在攻读高级学位或证书。 他们发表或出版了22篇同行评审论文，发表了62篇摘要，并获得了8个奖项。 所有毕业生都在学术岗位上。 研究重点是损伤机制，新的治疗方法，以及TBI和CA后的结果。使用由我们的教师联邦资助的研究支持的长凳到床边的方法。我们利用萨法尔复苏研究中心与匹兹堡儿童医院和匹兹堡大学医学院的PCCM、儿童神经病学、神经外科和PM&R培训计划之间的独特互动。主任、联合主任和主要培训师（PT）都是敬业的合格科学家和久经考验的教育工作者。每个导师的研究领域提出重要的问题，适合学员的职业发展和假设检验。我们还整合了神经重症监护研究课程。毕业生可以制定，执行，分析，演示和发布旨在回答关键问题的实验，并接受专业和研究完整性的培训。他们获得思考过程/工具来研究未来的问题。大多数培训通过传统的学徒制在PT的实验室进行。还包括儿科神经重症监护/研究方法的教学计划。每个研究员选择一个PT和一个专家监督小组委员会。培训在约50，000平方米的面积内进行。英尺设备齐全的实验室有行政/技术人员，以及临床研究的充足病例材料。正在开展平等权利行动征聘工作。

DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine (PCCM) specialists are the front line in neurointensive care. They respond to crises in the pediatric intensive care unit, including resuscitation and treatment of children with severe traumatic brain injury (TBI) and in-hospital cardiopulmonary arrest (CA). They interact with child neurology, neurological surgery, and physical medicine and rehabilitation (PM&R) specialists in the continuum of care. Our unique postdoctoral program trains PCCM, child neurology, neurological surgery and PM&R fellows in basic and clinical research in neurointensive care and resuscitation, establishing a link between trainees and senior scientists. In this revised competitive renewal application, funds are requested to support a total of 5 positions each yr. The program is completing its 5th year and has filled every position with high-quality fellows. Three have submitted and two have acquired K awards, and 5 have acquired or are pursuing advanced degrees or certificates. They have published or in press 22 peer-reviewed papers, presented 62 abstracts, and won 8 awards. All graduates are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. A bench-to-bedside approach supported by federally funded studies by our faculty is used. We capitalize on the unique interaction between the Safar Center for Resuscitation Research and the PCCM, child neurology, neurological surgery, and PM&R training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Med. The director, co-director, and principal trainers (PTs) are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for trainee career development and hypothesis testing. We also integrate a curriculum in neurointensive care research. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions, and are trained in grantsmanship and research integrity. They acquire the thought process/tools to study future questions. Most training takes place in the labs of the PTs via a classical apprenticeship. A didactic program in pediatric neurointensive care/research methods is also included. Each fellow chooses a PT and an expert supervising subcommittee. Training is carried out in ~50,000 sq. ft. of fully equipped lab space. Administrative/technical staff is available, as is ample case material for clinical research. Affirmative action recruitment efforts are in place.