Pediatric Neurointensive Care and Resuscitation Research

描述(由申请人提供)：儿科重症监护医学(PCCM)专家是神经重症监护的一线专家。他们对儿科重症监护病房的危机做出反应，包括对患有严重创伤性脑损伤(TBI)和住院心肺骤停(CA)的儿童进行复苏和治疗。他们与儿童神经学、神经外科、物理医学和康复(PM&R)专家在连续护理过程中进行互动。我们独特的博士后项目培训PCCM、儿童神经学、神经外科和PM&R研究员在神经重症监护和复苏方面的基础和临床研究，在受训者和资深科学家之间建立联系。在这份修订后的竞争性续签申请中，要求资金每年总共支持5个职位。该项目即将完成第五个年头，每个职位都有高素质的研究员。三人已提交，两人已获得K奖，5人已获得或正在攻读高级学位或证书。他们发表或出版了22篇同行评议论文，提交了62篇摘要，获得了8个奖项。所有的毕业生都在学术岗位上。研究重点集中在脑创伤和冠状动脉损伤后的损伤机制、新的治疗方法和结果。我们使用了一种由联邦政府资助的教职员工研究支持的床到床的方法。我们利用萨法尔复苏研究中心与匹兹堡儿童医院和大学的PCCM、儿童神经学、神经外科和PM&R培训项目之间的独特互动。来自匹兹堡医学院。主任、联席主任和首席培训师(PT)是敬业的、合格的科学家和经过验证的教育工作者。每个导师的研究领域都会提出重要的问题，适合学员的职业发展和假设检验。我们还整合了神经重症监护研究的课程。毕业生可以制定、执行、分析、展示和发表旨在回答关键问题的实验，并接受格兰特精神和研究诚信方面的培训。他们获得了研究未来问题的思维过程/工具。大多数培训都是通过传统的学徒制在PTS的实验室进行的。还包括一项儿童神经重症监护/研究方法的教学计划。每名院士选出一名PT和一名专家监督小组委员会。培训在约50,000平方米内进行。英国《金融时报》设备齐全的实验室空间。有行政/技术人员，也有充足的临床研究案例材料。平权行动招聘工作已经到位。

DESCRIPTION (provided by applicant): Pediatric Critical Care Medicine (PCCM) specialists are the front line in neurointensive care. They respond to crises in the pediatric intensive care unit, including resuscitation and treatment of children with severe traumatic brain injury (TBI) and in-hospital cardiopulmonary arrest (CA). They interact with child neurology, neurological surgery, and physical medicine and rehabilitation (PM&R) specialists in the continuum of care. Our unique postdoctoral program trains PCCM, child neurology, neurological surgery and PM&R fellows in basic and clinical research in neurointensive care and resuscitation, establishing a link between trainees and senior scientists. In this revised competitive renewal application, funds are requested to support a total of 5 positions each yr. The program is completing its 5th year and has filled every position with high-quality fellows. Three have submitted and two have acquired K awards, and 5 have acquired or are pursuing advanced degrees or certificates. They have published or in press 22 peer-reviewed papers, presented 62 abstracts, and won 8 awards. All graduates are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. A bench-to-bedside approach supported by federally funded studies by our faculty is used. We capitalize on the unique interaction between the Safar Center for Resuscitation Research and the PCCM, child neurology, neurological surgery, and PM&R training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Med. The director, co-director, and principal trainers (PTs) are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for trainee career development and hypothesis testing. We also integrate a curriculum in neurointensive care research. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions, and are trained in grantsmanship and research integrity. They acquire the thought process/tools to study future questions. Most training takes place in the labs of the PTs via a classical apprenticeship. A didactic program in pediatric neurointensive care/research methods is also included. Each fellow chooses a PT and an expert supervising subcommittee. Training is carried out in ~50,000 sq. ft. of fully equipped lab space. Administrative/technical staff is available, as is ample case material for clinical research. Affirmative action recruitment efforts are in place.