Pediatric Neurointensive Care and Resuscitation Research

描述（由申请人提供）：儿童急性危及生命的损伤，如创伤性脑损伤（TBI）和心脏骤停（CA）是发病率和死亡率的主要原因。这些损伤对中枢神经系统的损伤是不利结果的关键决定因素。这些神经系统和多系统损伤需要多学科和多部门的应对措施，必须从现场到康复进行协调。儿科神经重症监护和复苏的研究培训最好由平行的多学科和多部门计划提供。我们在萨法尔复苏研究中心独特的博士后项目，自2000年以来由T32支持，建立了脑损伤婴儿和儿童护理连续体的重要联系，并促进了关键学科的严格科学调查，包括儿科重症监护医学，儿童神经病学，儿科神经外科，儿科急诊医学，儿科学，儿科放射学，物理医学和康复。我们在神经重症监护和复苏的基础和临床研究中培训这些儿科学科的研究员，将他们与高级科学家联系起来。在此竞争性续约申请中，要求资金每年支持4个职位。自成立以来，该计划已经填补了高素质的研究员谁发表了许多同行评审的论文和摘要，并赢得了许多奖项的每一个位置。在上一个资助周期中，6名毕业研究员中有4名已经获得了5个K奖（两个K12，两个K 08和一个K23）;许多人获得了高级学位。他们作为教师备受追捧;所有人都在学术职位。研究重点是损伤机制，新的治疗方法，以及TBI和CA后的结果。我们使用由我们的教师联邦资助的研究支持的长凳到床边的方法。我们利用Safar中心与匹兹堡儿童医院和匹兹堡大学医学院培训项目之间的独特互动，并利用许多独特的资源和临床和转化科学研究所。主任，联合主任和导师都是敬业的，合格的科学家和久经考验的教育家。每个导师的研究领域提出重要的问题，适合职业发展和假设检验。我们整合了神经重症监护课程，并参与了独特的儿科神经重症监护临床服务。毕业生可以制定，执行，分析，演示和发布旨在回答关键问题的实验，并接受专业和研究完整性的培训。该方案在多样性招聘方面取得了成功，特别是在招聘残疾申请人方面。 公共卫生相关性：儿童急性危及生命的损伤，如创伤性脑损伤（TBI）和心脏骤停（CA）是发病率和死亡率的主要原因。这些神经系统和多系统的损害需要多学科和多部门的应对措施，必须从实地到康复进行协调。我们独特的多学科和多部门的博士后计划在萨法尔中心复苏研究和匹兹堡儿童医院，由T32自2000年以来的支持，建立了重要的联系，在整个连续照顾脑损伤的婴儿和儿童，并促进跨关键学科，包括儿科重症监护医学，儿童神经病学，儿科神经外科，儿科急诊医学、儿科学、儿科放射学、物理医学和康复。

DESCRIPTION (provided by applicant): Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. Injury to the central nervous system from these insults is the key determinant of unfavorable outcome. These neurological and multi- system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Research training in pediatric neurointensive care and resuscitation is best served by a parallel multidisciplinary and multi- departmental program. Our unique postdoctoral program at the Safar Center for Resuscitation Research, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates rigorous scientific investigation across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation. We train fellows in these pediatric disciplines in basic and clinical research in neurointensive care and resuscitation, linking them to senior scientists. In this competitive renewal application, funds are requested to support 4 positions each yr. Since its inception, the program has filled every position with high-quality fellows who have published numerous peer-reviewed papers and abstracts, and have won many awards. In the last funding cycle, 4 of the 6 graduated fellows have already acquired 5 K awards (two K12s, two K08s, and one K23); many have received advanced degrees. They are highly sought after as faculty; all are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. We use a bench-to-bedside approach supported by federally funded studies by our faculty. We capitalize on the unique interaction between the Safar Center and the training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Medicine and also take advantages of many unique resources and a Clinical and Translational Science Institute. The director, co-director, and mentors are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for career development and hypothesis testing. We integrate a curriculum in neurointensive care and involvement on a unique pediatric neurocritical care clinical service. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions and are trained in grantsmanship and research integrity. The program has had success in diversity recruitment, notably, in recruiting applicants with disabilities. PUBLIC HEALTH RELEVANCE: Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. These neurological and multi-system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Our unique multidisciplinary and multi-departmental postdoctoral program at the Safar Center for Resuscitation Research and Children's Hospital of Pittsburgh, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates training of clinician scientists across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation.