Pediatric Neurointensive Care and Resuscitation Research

儿科神经重症监护和复苏研究

• 批准号: 8277415
• 负责人: PATRICK M KOCHANEK
• 金额: $ 26.65万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277415
• 关键词: Caring; Childhood; Research; Resuscitation

DESCRIPTION (provided by applicant): Acute life-threatening insults in children such as traumatic brain injury (TBI) and cardiac arrest (CA) are leading causes of morbidity and mortality. Injury to the central nervous system from these insults is the key determinant of unfavorable outcome. These neurological and multi- system insults require a multidisciplinary and multi-departmental response that must be coordinated from the field through to rehabilitation. Research training in pediatric neurointensive care and resuscitation is best served by a parallel multidisciplinary and multi- departmental program. Our unique postdoctoral program at the Safar Center for Resuscitation Research, supported by a T32 since 2000, establishes important links across the continuum of care of brain injured infants and children and facilitates rigorous scientific investigation across the key disciplines including pediatric critical care medicine, child neurology, pediatric neurological surgery, pediatric emergency medicine, neonatology, pediatric radiology, and physical medicine and rehabilitation. We train fellows in these pediatric disciplines in basic and clinical research in neurointensive care and resuscitation, linking them to senior scientists. In this competitive renewal application, funds are requested to support 4 positions each yr. Since its inception, the program has filled every position with high-quality fellows who have published numerous peer-reviewed papers and abstracts, and have won many awards. In the last funding cycle, 4 of the 6 graduated fellows have already acquired 5 K awards (two K12s, two K08s, and one K23); many have received advanced degrees. They are highly sought after as faculty; all are in academic positions. The research focus is on injury mechanisms, novel therapies, and outcomes after TBI and CA. We use a bench-to-bedside approach supported by federally funded studies by our faculty. We capitalize on the unique interaction between the Safar Center and the training programs at Children's Hospital of Pittsburgh and the Univ. of Pittsburgh School of Medicine and also take advantages of many unique resources and a Clinical and Translational Science Institute. The director, co-director, and mentors are dedicated, qualified scientists and proven educators. The research areas of each mentor ask important questions, suitable for career development and hypothesis testing. We integrate a curriculum in neurointensive care and involvement on a unique pediatric neurocritical care clinical service. Graduates can formulate, execute, analyze, present and publish experiments designed to answer key questions and are trained in grantsmanship and research integrity. The program has had success in diversity recruitment, notably, in recruiting applicants with disabilities.

描述（由申请人提供）：诸如创伤性脑损伤（TBI）和心脏骤停（CA）等儿童的急性威胁生命的侮辱是发病率和死亡率的主要原因。这些侮辱对中枢神经系统的伤害是不利结果的关键决定因素。这些神经系统和多系统的侮辱需要多学科和多部门的反应，必须从现场到康复进行协调。与平行的多学科和多部门计划最好地为儿科神经护理和复苏的研究培训提供了最好的服务。自2000年以来，我们在T32的支持下，我们在萨法尔复苏研究中心的独特博士后计划建立了重要的联系，包括脑受伤的婴儿和儿童的护理连续性，并促进了跨关键科道的严格科学研究康复。我们在这些小儿学科中的研究员在神经性护理和复苏方面的基础和临床研究中培训研究员，并将其与高级科学家联系起来。在此竞争性更新申请中，要求资金每年支持4个职位。自成立以来，该计划就填补了每个职位的高质量研究员，他们发表了许多同行评审的论文和摘要，并赢得了许多奖项。在最后一个资金周期中，6个毕业研究员中有4个已经获得了5个奖项（两个K12，两个K08和一个K23）；许多人获得了高级学位。作为教师，他们受到了极大的追捧。所有人都处于学术职位。研究重点是TBI和CA之后的损伤机制，新型疗法和结果。我们使用基于联邦资助的研究支持的基准旁边的方法。我们利用匹兹堡儿童医院和大学儿童医院的野生动物园中心与培训计划之间的独特互动。匹兹堡医学院的雕像，还利用了许多独特的资源和临床和转化科学研究所的优势。董事，联合导演和导师是敬业的，合格的科学家和经过验证的教育者。每个导师的研究领域都提出重要问题，适合职业发展和假设检验。我们整合了神经性护理的课程，并参与了独特的儿科神经护理临床服务。毕业生可以制定，执行，分析，介绍和发布旨在回答关键问题的实验，并接受授予和研究完整性的培训。该计划在多样性招聘方面取得了成功，尤其是在招募残疾申请人方面。