Molecular Biology and Gene Therapy in Burns and Trauma

烧伤和创伤的分子生物学和基因治疗

• 批准号: 7079361
• 负责人: LYLE L MOLDAWER
• 金额: $ 11.6万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7079361
• 关键词: Molecular; Biology; Gene; Therapy; Burns

DESCRIPTION (provided by applicant): The overall goal of this training program is to provide a focused two year research experience for two surgical residents-in-training or other clinical house officers expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy as it applies to inflammation research in trauma, sepsis and burns. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of gene therapy, functional genomics and molecular biology, as well as the developing collaborations between nationally recognized basic scientists and clinicians dedicated to the training of future clinical academicians. The interface between the basic science of gene therapy, functional genomics and molecular biology, and inflammation research will be targeted to the problems of adult respiratory distress syndrome (ARDS), SIRS or sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, and CNS injury. The faculty will be drawn from basic scientists in the Departments of Surgery, Obstetrics and Gynecology, Neuroscience and Molecular Genetics and Microbiology at the University of Florida College of Medicine, who will serve as research mentors to the trainees. Clinical mentors from the Departments of Surgery and Anesthesiology (Critical Care Medicine) will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine Department of Surgery General Surgery Residency Program. Successful applicants will with the assistance of the Executive Committee identify a research and clinical mentor who will assist in the formulation of a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology and gene therapy. Furthermore, trainees are expected to participate in seminars in the Gene Therapy Center, and in their basic science departments, as well as weekly laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.

描述（由申请人提供）：该培训计划的总体目标是为两名外科住院医师提供为期两年的研究经验，培训或其他临床住院医师表示致力于创伤，损伤，烧伤或炎症研究的职业生涯。该研究计划将侧重于掌握分子生物学，功能基因组学和基因治疗，因为它适用于创伤，脓毒症和烧伤的炎症研究。该计划将利用医学院在基因治疗，功能基因组学和分子生物学领域的独特优势，以及国家认可的基础科学家和临床医生之间的合作，致力于培养未来的临床院士。基因治疗、功能基因组学和分子生物学的基础科学与炎症研究之间的接口将针对成人呼吸窘迫综合征（ARDS）、SIRS或脓毒症综合征、缺血/再灌注损伤、延迟伤口愈合和烧伤伤口以及CNS损伤的问题。教员将从佛罗里达大学医学院外科、妇产科、神经科学和分子遗传学及微生物学系的基础科学家中抽调，他们将担任受训人员的研究导师。来自外科和麻醉科（重症监护医学）的临床导师将与学员和研究人员互动，以确保学员接触到 炎症研究中的临床重要问题。 该计划的总体方向将取决于主要研究者和执行委员会。 奖学金的候选人将在全国范围内招募，并从佛罗里达大学医学院外科系普外科住院医师项目。成功的申请者将在执行委员会的协助下确定一名研究和临床导师，该导师将协助制定正式的培训计划并定期审查受训者的进展。培训计划的大部分将在一位经验丰富的研究导师的实验室进行，但学员也将被要求完成研究伦理和统计方法的基本课程，并将被鼓励获得分子生物学和基因治疗方面的补充教学培训。此外，受训人员还将参加基因治疗中心及其基础科学部门的研讨会，以及每周的实验室研究会议。他们还将参加临床研讨会，包括外科和重症监护医学大查房。预计成功的毕业生将拥有足够的研究技能，以竞争炎症研究的过渡资金。