Function of Flightless I in the skin blistering disorder epidermolysis bullosa

Flightless I 在皮肤起泡性疾病大疱性表皮松解症中的作用

• 批准号: nhmrc : 626802
• 负责人: A/Pr Ruth Arkell
• 金额: $ 38.59万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-flightless-i-epidermolysis-bullosa/101321
• 关键词: Function; Flightless; skin; blistering; disorder

Skin blistering disorders are painful and debilitating. They can lead to permanent scarring and may be life threatening within two years of birth. No specific cure exists. Our previous studies have identified the important role of Flii in wound healing. We now aim to investigate the potential function of Flii in skin blistering disorders. We will also determine whether modulating Flii reduces blister formation. This research could lead to new therapies for treating people with fragile skin.

皮肤起疱性疾病是痛苦和虚弱的。它们会导致永久性的疤痕，并可能在出生两年内危及生命。目前尚无特效药。我们之前的研究已经确定了Flii在伤口愈合中的重要作用。我们现在的目标是研究Flii在皮肤起泡疾病中的潜在功能。我们还将确定调节Flii是否会减少水疱的形成。这项研究可能会为治疗皮肤脆弱的人带来新的疗法。