Mechanism of Flightless I function in burn injury and scar formation

Flightless I在烧伤和疤痕形成中的作用机制

• 批准号: nhmrc : 565004
• 负责人: A/Pr Ruth Arkell
• 金额: $ 36.36万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-flightless-i-scar-formation/99929
• 关键词: Mechanism; Flightless; function; burn; injury

Extensive scarring is a major clinical problem often resulting from burn injuries. We have previously shown that the cytoskeletal protein, Flightless I (FliI), is an important regulator of wound repair. We now plan to investigate whether FliI is also be the mechanistic link between cytoskeletal remodelling and induction of TGF-betas post-wounding leading to scar formation.

广泛的瘢痕形成是一个主要的临床问题，通常由烧伤引起。我们以前已经表明，细胞骨架蛋白，Flightless I（FliI），是一个重要的调节伤口修复。我们现在计划研究FliI是否也是创伤后导致瘢痕形成的细胞骨架重塑和TGF-β诱导之间的机制联系。