The ZIC3 Heterotaxy-associated transcription factor: a new player in nuclear control of canonical Wnt signalling

ZIC3异序相关转录因子：经典Wnt信号传导核控制的新参与者

• 批准号: nhmrc : 1126288
• 负责人: A/Pr Ruth Arkell
• 金额: $ 67.82万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/zic3-heterotaxy-associated-wnt-signalling/947761
• 关键词: ZIC3; Heterotaxy; associated; transcription; factor

Humans have many internal asymmetries that need to occur in a consistent manner across all individuals. Examples of asymmetry include our unpaired organs (like the heart or liver) or a paired organ with asymmetry (like the lungs). In this project we will use cutting edge molecular embryology and cell biology techniques to explore the mechanisms behind the remarkable feat of establishing asymmetry so we are better able to help those individuals with laterality disorders.

人类有许多内在的不对称性，需要在所有个体中以一致的方式发生。不对称的例子包括我们不配对的器官（如心脏或肝脏）或不对称的配对器官（如肺）。在这个项目中，我们将使用尖端的分子胚胎学和细胞生物学技术来探索建立不对称性这一非凡壮举背后的机制，以便我们能够更好地帮助那些患有偏侧性障碍的个体。