Training Cellular Signalling in Cardiovascular System

训练心血管系统中的细胞信号传导

• 批准号: 7078652
• 负责人: R John Solaro
• 金额: $ 70.58万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7078652
• 关键词: Training; Cellular; Signalling; Cardiovascular; System

DESCRIPTION (provided by applicant): The objective of the training program is to provide an environment for the generation of cardiovascular scientists with the capability moving through the continuum of investigations linking genomic and proteomic information to the understanding of complex systems, and translating this information to the diagnosis, treatment and prevention of diseases of the heart and blood vessels. A theme of the program is the integration of understanding at the levels of molecules and cells to the systems biology of cardiovascular function at the levels of the dynamics of and activity of tissues, organs, and animals. Two major institutions in Chicago, The University of Illinois at Chicago (UIC) and Rush University College of Medicine, have been working together for the past 14 years to meet these objectives in a joint training effort. This long standing interaction provides a unique and diverse training environment with a common thread of emphasis on integrated control mechanisms and translational research. Focus areas include physiological and pathophysiological phenotyping; endocrine and paracrine signaling! channels, receptors, G proteins, and transporters; excitation-contraction coupling; protein phosphorylation and sarcomeric motor and regulatory proteins; and, regulation of transcription and translation. A strength of the program is a seamless training environment where trainees collaborate with teams of investigators in joint projects. Pre-doctoral candidates enter the program after a successful year of graduate study in the core curriculum of the UIC Graduate Education in Medical Sciences (GEMS)Program. they continue training in various areas of specialization including Physiology and Biophysics, Biological Chemistry and Molecular Biology, Cell Biology, and Pharmacology. Students write and orally defend a formal pre-thesis proposal along the NIH or AHA format. The pre-doctoral curriculum is supplemented by required upper level graduate course in areas of special interest including courses on control theory, system biology, techniques, concepts, and strategies of scientific enquiry. Training includes the opportunity to pursue in depth informatics associated with genomic and proteomic information as well the opportunity to purse in depth training in systems and computational biology. Post-doctoral students are trained in two or three year programs tailored to their career objectives, background, and specific course needs. (END OF ABSTRACT)

描述(由申请人提供)： 培训计划的目的是为心血管科学家的产生提供一个环境，使他们有能力完成将基因组和蛋白质组信息与复杂系统的理解联系起来的连续研究，并将这些信息转化为心脏和血管疾病的诊断、治疗和预防。该计划的一个主题是将分子和细胞水平的理解整合到组织、器官和动物的动态和活动水平上的心血管功能的系统生物学。芝加哥的两个主要机构，伊利诺伊大学芝加哥分校(UIC)和拉什大学医学院，在过去的14年里一直在共同努力，通过联合培训努力实现这些目标。这种长期的互动提供了一个独特和多样化的培训环境，强调综合控制机制和转化性研究的共同主线。重点领域包括生理和病理生理表型；内分泌和旁分泌信号！通道、受体、G蛋白和转运体；兴奋-收缩偶联；蛋白质磷酸化和肌瘤马达和调节蛋白；以及转录和翻译的调节。该项目的一个优势是无缝的培训环境，受训者在联合项目中与调查团队合作。博士前候选人在UIC医学研究生教育(GEMS)项目的核心课程中成功完成一年的研究生学习后进入该项目。他们继续在不同的专业领域接受培训，包括生理学和生物物理学、生物化学和分子生物学、细胞生物学和药理学。学生以NIH或AHA的形式撰写并口头辩护一份正式的论文前提案。博士前课程的补充是特别感兴趣的领域的必修高级研究生课程，包括控制理论、系统生物学、技术、概念和科学探究策略的课程。培训包括有机会深入研究与基因组和蛋白质组信息有关的信息学，以及有机会在系统和计算生物学方面进行深入培训。博士后根据他们的职业目标、背景和特定的课程需求进行两到三年的培训。(摘要结束)