Training Cellular Signalling in Cardiovascular System

训练心血管系统中的细胞信号传导

• 批准号: 7623072
• 负责人: R John Solaro
• 金额: $ 40万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7623072
• 关键词: Cardiovascular system; Signal Transduction; Training

DESCRIPTION (provided by applicant): The objective of the training program is to provide an environment for the generation of cardiovascular scientists with the capability moving through the continuum of investigations linking genomic and proteomic information to the understanding of complex systems, and translating this information to the diagnosis, treatment and prevention of diseases of the heart and blood vessels. A theme of the program is the integration of understanding at the levels of molecules and cells to the systems biology of cardiovascular function at the levels of the dynamics of and activity of tissues, organs, and animals. Two major institutions in Chicago, The University of Illinois at Chicago (UIC) and Rush University College of Medicine, have been working together for the past 14 years to meet these objectives in a joint training effort. This long standing interaction provides a unique and diverse training environment with a common thread of emphasis on integrated control mechanisms and translational research. Focus areas include physiological and pathophysiological phenotyping; endocrine and paracrine signaling! channels, receptors, G proteins, and transporters; excitation-contraction coupling; protein phosphorylation and sarcomeric motor and regulatory proteins; and, regulation of transcription and translation. A strength of the program is a seamless training environment where trainees collaborate with teams of investigators in joint projects. Pre-doctoral candidates enter the program after a successful year of graduate study in the core curriculum of the UIC Graduate Education in Medical Sciences (GEMS)Program. they continue training in various areas of specialization including Physiology and Biophysics, Biological Chemistry and Molecular Biology, Cell Biology, and Pharmacology. Students write and orally defend a formal pre-thesis proposal along the NIH or AHA format. The pre-doctoral curriculum is supplemented by required upper level graduate course in areas of special interest including courses on control theory, system biology, techniques, concepts, and strategies of scientific enquiry. Training includes the opportunity to pursue in depth informatics associated with genomic and proteomic information as well the opportunity to purse in depth training in systems and computational biology. Post-doctoral students are trained in two or three year programs tailored to their career objectives, background, and specific course needs. (END OF ABSTRACT)

描述（由申请人提供）： 培训计划的目标是为心血管科学家的一代提供一个环境，使他们能够通过连续的调查将基因组和蛋白质组信息与复杂系统的理解联系起来，并将这些信息转化为心脏和血管疾病的诊断，治疗和预防。该计划的一个主题是在分子和细胞水平上的理解与心血管功能的系统生物学在组织，器官和动物的动态和活动水平上的整合。芝加哥的两个主要机构，伊利诺伊大学芝加哥分校（UIC）和拉什大学医学院，在过去的14年里一直在共同努力，以满足这些目标的联合培训工作。这种长期的互动提供了一个独特而多样化的培训环境，重点是综合控制机制和转化研究。重点领域包括生理和病理生理表型;内分泌和旁分泌信号！通道、受体、G蛋白和转运蛋白;兴奋-收缩偶联;蛋白质磷酸化和肌节运动和调节蛋白;以及转录和翻译的调节。该计划的优势是一个无缝的培训环境，学员与联合项目的调查团队合作。博士前候选人在UIC医学科学研究生教育（GEMS）计划的核心课程研究生学习成功一年后进入该计划。他们继续在各个专业领域的培训，包括生理学和生物物理学，生物化学和分子生物学，细胞生物学和药理学。学生写和口头辩护一个正式的论文前的建议沿沿着美国国立卫生研究院或AHA格式。博士前课程由特别感兴趣的领域所需的高级研究生课程补充，包括控制理论，系统生物学，技术，概念和科学探究策略的课程。培训包括有机会深入研究与基因组和蛋白质组学信息相关的信息学，以及有机会在系统和计算生物学方面进行深入培训。博士后学生接受两三年的培训，根据他们的职业目标，背景和具体课程需求量身定制。(END（见摘要）