Function of a novel interferon in reproductiona and development

新型干扰素在生殖和发育中的功能

• 批准号: nhmrc : 384261
• 负责人: Prof Paul Hertzog
• 金额: $ 33.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-novel-interferon-reproductiona-development/97942
• 关键词: Function; novel; interferon; reproductiona; development

It is important to understand the factors responsible for maintaining fertility, pregnancy and to prevent infection of the developing fetus and the uterus. The latter is an important general problem in women. We have identified a new protein that our current evidence suggests is involved in reproduction, embryonic or fetal development. This new protein is related tot he interferon family of proteins that are best characterised by their important functions in protecting the host from viral infections and cancer. We propose to undetake a detailed study to determine when and where the new interferon is produced in the reproductive tract and during pregnancy and its importance in the maintenance of pregnancy and in protection against fetal-uterine infection.

重要的是要了解维持生育、怀孕和预防发育中的胎儿和子宫感染的因素。后者是妇女普遍存在的一个重要问题。我们已经确定了一种新的蛋白质，我们目前的证据表明，这种蛋白质与生殖、胚胎或胎儿发育有关。这种新的蛋白质与干扰素家族的蛋白质有关，干扰素家族的最大特点是在保护宿主免受病毒感染和癌症方面具有重要功能。我们建议进行一项详细的研究，以确定新的干扰素在何时何地在生殖道和怀孕期间产生，以及它在维持妊娠和预防胎儿-子宫感染方面的重要性。