Characterising the novel signalling mechanism for a new interferon

表征新干扰素的新颖信号传导机制

• 批准号: nhmrc : 1049686
• 负责人: Prof Paul Hertzog
• 金额: $ 35.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-novel-signalling-new-interferon/112104
• 关键词: Characterising; novel; signalling; mechanism; new

We have discovered a new regulatory protein called interferon epsilon, made in the female reproductive tract and is crucial for protection against bacterial( Chlamydia) and viral (Herpes Simplex Virus) infections. However, we are yet to understand how it interacts with target cells. This grant will study how IFN? binds to cells and the nature of the signals it transmits. This will help us understand its role in disease and its clinical potential

我们发现了一种新的调节蛋白，称为干扰素β，在女性生殖道中产生，对防止细菌（衣原体）和病毒（单纯疱疹病毒）感染至关重要。然而，我们还不知道它如何与靶细胞相互作用。本研究将资助如何干扰素？与细胞结合并传递信号。这将有助于我们了解它在疾病中的作用及其临床潜力