Breast Cancer Surveillance in a Defined Population

特定人群的乳腺癌监测

基本信息

项目摘要

This proposed project takes advantage of comprehensive surveillance data on more than 100,000 women offered breast cancer screening through a program with mailed reminders to schedule mammography examinations within a managed care plan (Group Health Cooperative of Puget Sound, GHC). Cancer outcome (mortality, late-stage disease) for the target population are collected through a Surveillance, Epidemiology, and End Results reporting (SEER) registry and are linked to health care process data (service use, mammography assessments). This proposal includes 3 specific aims: 1) To continue breast cancer data system development at GHC to; a) improve data system software, enhance data storage capabilities, and facilitate data retrieval; b) incorporate new data components pertinent to research, such as a targeted survey; and c) maintain and improve data quality assurance, report generation, and data file development; 2) To use the data system to conduct 5 initiatives: a) The effect of short-term hormone replacement therapy (HRT) cessation on mammographic density; b) The likelihood of additional imaging (mammography and ultrasound) and the associated costs among women stopping HRT compared to women continuing or never using HRT; C) The factors that explain the reduced sensitivity of mammography among younger women; d) The biologic and other factors that influence the likelihood of late-stage disease; and, e) The effect of screening interval on stage at-diagnosis; and 3) To conduct 5 research projects related to screening mammography: a) The additional effect of mammographic breast density on the 5-year risk of breast cancer; b) Screening sensitivity and specificity by phase of menstrual cycle; c) The association between mammographic findings and cancer among women with "probably benign findings"; d) The effect of computer assisted reading on mammography interpretive performance; and e) Biomarkers associated with nodal metastases at-diagnosis among screened women. By continuing our multi disciplinary collaboration and using carefully designed prospective observational and evaluative studies the investigators will contribute to improvements in breast cancer screening, and the understanding of breast cancer biology.
这个拟议的项目利用了对100,000多名妇女的全面监测数据,该妇女通过一个项目提供乳腺癌筛查,并通过邮寄提醒在管理性保健计划(Puget Sound的团体健康合作社,GHC)内安排乳房X光检查。目标人群的癌症结果(死亡率、晚期疾病)通过监测、流行病学和最终结果报告(SEER)登记收集,并与卫生保健过程数据(服务使用、乳房X光检查评估)相联系。该建议包括3个具体目标:1)继续在GHC开发乳腺癌数据系统;a)改进数据系统软件,增强数据存储能力,并促进数据检索;b)纳入与研究有关的新数据组成部分,如有针对性的调查;以及c)保持和改进数据质量保证、报告生成和数据文件开发;2)使用数据系统进行5项倡议:a)停止短期激素替代疗法(HRT)对乳房X光照相密度的影响;B)停止HRT的妇女与继续或从不使用HRT的妇女相比,停止HRT的可能性和相关费用;c)解释年轻妇女乳房X光检查敏感性降低的因素;d)影响晚期疾病可能性的生物学因素和其他因素;e)筛查间隔对诊断阶段的影响;以及3)开展与筛查乳房X光检查有关的5个研究项目:a)乳房X光检查对5年乳腺癌风险的额外影响;b)按月经周期阶段筛查敏感性和特异性;C)“可能是良性发现”的妇女的乳房X光检查结果与癌症之间的联系;d)计算机辅助阅读对乳房X光检查解释能力的影响;e)筛查妇女诊断时与结节转移有关的生物标记物。通过继续我们的多学科合作,并使用精心设计的前瞻性观察和评估研究,研究人员将为改进乳腺癌筛查和了解乳腺癌生物学做出贡献。

项目成果

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DIANA SM BUIST其他文献

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{{ truncateString('DIANA SM BUIST', 18)}}的其他基金

Self-Testing Options in the era of Primary HPV screening for cervical cancer: the STEP trial
宫颈癌初级 HPV 筛查时代的自我检测选择:STEP 试验
  • 批准号:
    10468556
  • 财政年份:
    2019
  • 资助金额:
    $ 40.83万
  • 项目类别:
Self-Testing Options in the era of Primary HPV screening for cervical cancer: the STEP trial
宫颈癌初级 HPV 筛查时代的自我检测选择:STEP 试验
  • 批准号:
    9796573
  • 财政年份:
    2019
  • 资助金额:
    $ 40.83万
  • 项目类别:
CATALyST: Consortium for Applied Training to Advance the Learning health system with Scholars/Trainees
CATAlyST:与学者/受训者一起推进学习健康系统的应用培训联盟
  • 批准号:
    9788231
  • 财政年份:
    2018
  • 资助金额:
    $ 40.83万
  • 项目类别:
CATALyST: Consortium for Applied Training to Advance the Learning health system with Scholars/Trainees
CATAlyST:与学者/受训者一起推进学习健康系统的应用培训联盟
  • 批准号:
    10018012
  • 财政年份:
    2018
  • 资助金额:
    $ 40.83万
  • 项目类别:
Oral contraceptive use by formulation and breast cancer risk by subtype
按配方划分的口服避孕药使用情况和按亚型划分的乳腺癌风险
  • 批准号:
    7885296
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
Comparative effectiveness of breast imaging strategies in community practice
社区实践中乳腺成像策略的比较有效性
  • 批准号:
    7861090
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
Comparative effectiveness of breast imaging strategies in community practice
社区实践中乳腺成像策略的比较有效性
  • 批准号:
    7944143
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
Oral contraceptive use by formulation and breast cancer risk by subtype
按配方划分的口服避孕药使用情况和按亚型划分的乳腺癌风险
  • 批准号:
    7740890
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
SEARCH: Cancer Screening Effectiveness and Research in Community-based Healthcare
搜索:癌症筛查有效性和社区医疗保健研究
  • 批准号:
    7861035
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
SEARCH: Cancer Screening Effectiveness and Research in Community-based Healthcare
搜索:癌症筛查有效性和社区医疗保健研究
  • 批准号:
    7944095
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:

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COOPERATIVE AGREEMENT WITH THE PAN AMERICAN HEALTH ORGANIZATION
与泛美卫生组织的合作协议
  • 批准号:
    9065935
  • 财政年份:
    2014
  • 资助金额:
    $ 40.83万
  • 项目类别:
COOPERATIVE AGREEMENT WITH THE PAN AMERICAN HEALTH ORGANIZATION
与泛美卫生组织的合作协议
  • 批准号:
    8788900
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与泛美卫生组织(PAHO)的合作协议
  • 批准号:
    8732111
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    2010
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Cooperative Agreement with Pan American Health Organization (PAHO)
与泛美卫生组织(PAHO)的合作协议
  • 批准号:
    8145578
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    2010
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与泛美卫生组织(PAHO)的合作协议
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    8529690
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    2010
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    $ 40.83万
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Cooperative Agreement with Pan American Health Organization (PAHO)
与泛美卫生组织(PAHO)的合作协议
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    8333850
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    2010
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与泛美卫生组织(PAHO)的合作协议
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    8542496
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与泛美卫生组织(PAHO)的合作协议
  • 批准号:
    8140030
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    2010
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AMERICAN SAMOA AFFILIATED COLLABORATIVE PERFORMANCE AGREEMENT FOR TOBACCO CONTROL
美属萨摩亚附属烟草控制合作履约协议
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    8450040
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    8054728
  • 财政年份:
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