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SEARCH: Cancer Screening Effectiveness and Research in Community-based Healthcare

搜索：癌症筛查有效性和社区医疗保健研究

基本信息

批准号：
7944095
负责人：
DIANA SM BUIST
金额：
$ 199.17万
依托单位：
KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944095
关键词：
Address Adherence Adverse effects Age Algorithms Area Cancer Burden Cancer Center Cancer Intervention and Surveillance Modeling Network Cancer Research Network Clinical Practice Guideline Clinical Trials Collaborations Colonoscopy Colorectal Colorectal Cancer Communities Community Health Cytology Data Data Set Data Sources Decision Making Detection Diagnostic Diagnostic Neoplasm Staging Early Diagnosis Effectiveness Flexible fiberoptic sigmoidoscopy Foundations Funding Future Goals Grant Hawaii Health Health Personnel Health Planning Health Policy Health Services Research Healthcare Healthcare Systems Individual Integrated Delivery of Health Care Intervention Liquid substance Malignant Neoplasms Malignant neoplasm of cervix uteri Medical Methods Modeling Morbidity - disease rate National Cancer Advisory Board Pap smear Patients Performance Policies Policy Maker Population Population Group Population Heterogeneity Positioning Attribute Premalignant Preventive Process Prospective Studies Provider Public Health Recommendation Recovery Relative (related person)Research Research Infrastructure Research Personnel Risk Scientist Screening for cancer Screening procedure Services Site Staging System Testing Translating Translations United States Woman Work base cancer prevention care delivery career development clinical practice community setting comparative effectiveness compare effectiveness cost effectiveness design effectiveness research health care delivery health care service utilization improved innovation meetings mortality population based prevent programs prospective public health relevance research study response success virtual

项目摘要

DESCRIPTION (Provided by the applicant): Improvements in cancer screening effectiveness, higher participation rates and faster introduction of new screening tests could have pronounced effects on the health of the community by reducing cancer burden. Cancer screening effectiveness in real-world settings depends not only on the efficacy of individual tests but also on patients, health care providers, and the systems and context in which health care is delivered. Large and well defined populations of enrollees with diverse data sources are fundamental for comparative effectiveness research that addresses health policy questions about cancer screening delivery. In response to the Grand Opportunity (GO), we propose to create an innovative and sustainable multi-disciplinary and multi-institutional virtual center for cancer SEARCH: Screening Effectiveness And Research in Community-based Healthcare within the NCI-funded Cancer Research Network (CRN). Because SEARCH is set in CRN-affiliated health care delivery systems across the United States, it will benefit directly from the strong foundation of an existing and well-established network of NCI-funded research infrastructure. An innovative portion of SEARCH will be our ability to translate and disseminate of our findings directly into practice. We have identified and engaged a national Advisory Board of cancer screening experts and have proposed a new collaboration with the Cancer Intervention and Surveillance Modeling Network (CISNET). Together, we will pursue high priority comparative effectiveness research (CER) that has relevance to clinicians, patients, policy makers, payers, public health practitioners and medical associations. Our specific aims over the two-year grant period are to: 1) Create a multi-disciplinary, multi-site team for CER focused on the delivery of cancer screening in community-based settings; 2) Develop methodological capacity for future large-scale, population-based CER studies; 3) Demonstrate our ability to conduct CER in the area of cancer screening to address important evidence gaps. Eight CRN sites will be involved in this application with four sites (Group Health, Kaiser Northwest and Hawaii, and Fallon) contributing data for the proof of principle studies. We expect SEARCH will serve as a productive platform for launching larger CER studies. During the two year funding period, we will build necessary infrastructure and collaborations, and will seek additional funding to address important questions on the quality and effectiveness of cancer screening care delivery in community-based health care systems. PUBLIC HEALTH RELEVANCE: Large and well defined populations of enrollees with diverse data sources are fundamental for comparative effectiveness research that addresses health policy questions about cancer screening delivery. We plan to study approaches to effectively deliver cancer screening to populations in order to enhance detection, diminish morbidity and other adverse effects, and ultimately reduce mortality. The SEARCH: Screening Effectiveness And Research in Community-based Healthcare research team will be based within the geographically diverse health care systems of the NCI-funded Cancer Research Network, which is a consortium of 14 health plans across the US, and will enable translation of our findings directly into clinical practice in community settings.

描述(申请人提供)：癌症筛查效率的提高、更高的参与率和更快地引入新的筛查测试，可能会通过减轻癌症负担而对社区的健康产生显著影响。现实世界中癌症筛查的有效性不仅取决于个别检测的效果，还取决于患者、卫生保健提供者以及提供卫生保健的系统和背景。具有不同数据来源的大量和定义明确的参与者是比较有效性研究的基础，该研究解决了关于癌症筛查交付的卫生政策问题。为了应对这一重大机遇(GO)，我们建议在NCI资助的癌症研究网络(CRN)内创建一个创新和可持续的多学科、多机构的癌症研究虚拟中心：筛查有效性和社区医疗研究。由于搜索设置在美国各地CRN附属的医疗保健提供系统中，它将直接受益于NCI资助的现有和成熟的研究基础设施网络的强大基础。搜索的一个创新部分将是我们将我们的发现直接转化和传播到实践中的能力。我们已经确定并聘请了一个由癌症筛查专家组成的国家咨询委员会，并提议与癌症干预和监测建模网络(CISNET)开展新的合作。我们将共同开展与临床医生、患者、政策制定者、支付者、公共卫生从业者和医学协会相关的高度优先的比较有效性研究(CER)。在两年的资助期内，我们的具体目标是：1)为CER创建一个多学科、多地点的团队，专注于在社区环境中提供癌症筛查；2)为未来基于人群的大规模CER研究发展方法学能力；3)展示我们在癌症筛查领域进行CER以弥补重要证据空白的能力。8个CRN站点将参与这项申请，其中4个站点(Group Health、Kaiser Northwest和Hawaii以及Fallon)为原则研究的证明提供数据。我们预计搜索将成为启动更大规模的CER研究的富有成效的平台。在两年的资助期内，我们将建立必要的基础设施和合作，并将寻求额外的资金，以解决社区医疗系统中癌症筛查护理服务的质量和有效性的重要问题。公共卫生相关性：具有不同数据来源的大量和定义明确的登记人口是解决癌症筛查提供的卫生政策问题的比较有效性研究的基础。我们计划研究有效地向人群提供癌症筛查的方法，以提高检测能力，减少发病率和其他不利影响，并最终降低死亡率。搜索：筛查有效性和基于社区的医疗研究团队将在NCI资助的癌症研究网络的不同地理位置的医疗系统中工作，该网络是一个由全美14个健康计划组成的联盟，将使我们的发现直接转化为社区环境中的临床实践。