Understanding the impact of the Covid-19 pandemic on the mental health of children and young people with pre-existing mental health conditions

尽管儿童和年轻人（CYP）仅占全球冠状病毒病（Covid-19）患者的1% -2%，但他们及其家人受到了疫情的重大影响。新出现的研究表明，反复的间歇性封锁、长期的社会隔离、对感染的恐惧、学校关闭和家庭压力增加的长期后遗症对CYP的心理健康产生了不利影响（例如Newlove-Delgado等人，2021年）。此外，有些人还可能患上与Covid-19感染相关的长期疾病（Long Covid-19），这可能进一步加剧心理健康状况不佳（Stephenson等人，2022）。先前存在精神健康问题的青少年可能特别容易受到伤害，但关于这一人群的代表性流行病学数据有限。我们之前在儿童和青少年心理健康服务（CAMHS）下对2500名青少年进行的调查显示，那些患有神经发育障碍的人受影响最大，情绪和行为变化更糟，但在遵守社交距离和参与在线教育方面也更困难（Parlatini等人，在准备中）。因此，先前存在的心理健康状况可能会对CYP适应快速变化的弹性和灵活性产生负面影响。不幸的是，在以往疫情文献的支持下（sprung & Silman, 2013），人们越来越担心，由于持续的不确定性、教育机会的快速变化、家庭压力和服务支持的减少，对心理健康的影响可能会随着时间的推移变得更加明显。此外，已存在的精神健康状况已被确定为成人长期感染的风险因素，重要的是要了解患有先前存在的精神健康状况的CYP是否也可能面临更高的风险，以及他们如何受到长期感染的影响。最后，大约三分之一的被调查家庭报告说，CAMHS没有满足他们的需求，目前尚不清楚这是否与从面对面干预到远程干预的过渡有关。这也强调了开发一个有效系统的必要性，以便将个人调查结果快速传达给临床医生，从而实现有效的随访和服务规划。大流行及其对儿童心理健康的限制的重要性已得到充分认识；最近，英国对Covid -18大流行及其处理的调查特别扩大到包括CYP的心理健康。帮助临床医生了解哪些患者面临最大风险；随着时间的推移，社交距离限制和学校提供的变化可能对他们产生不同的影响；因此，所提供的护理是否满足他们的需求，对于有效应对当前的大流行和为未来的任何情况做出计划至关重要。通过建立临床结果的横断面探索性模型，了解大流行的不同方面，从社会距离到对家庭经济和教育的影响，如何与covid前儿童因素（如年龄、性别和诊断）和社会人口学特征（如种族和家庭情况）相互作用，并对已有心理健康状况的慢性阻塞性睡眠障碍患者的心理健康产生不同影响。通过在重要时间点（例如学校关闭和重新开放）重新检测样本，并根据纵向数据对临床结果的轨迹进行建模，了解随大流行演变而发生的社会距离限制和教育提供等时效性因素的影响。通过对已有精神健康状况的CYP及其家人进行定性半结构化访谈，探讨Covid-19期间结果变化的潜在机制。

Although children and young people (CYP) represent only 1-2% of those with Coronavirus disease (Covid-19) globally, they and their families have been significantly affected by the pandemic. Emerging research suggests that the long-term sequelae of repeated intermittent lockdowns, prolonged social isolation, fear of infection, school closures and increased family pressures have had detrimental effects on the mental health of CYP (e.g. Newlove-Delgado et al., 2021). Moreover, some may also develop long-term illness linked to Covid-19 infection (Long Covid-19), which may further exacerbate poor mental health (Stephenson et al., 2022). CYP with pre-existing mental health conditions may be particularly vulnerable, but there are limited representative epidemiological data on this population. Our previous survey of 2500 CYP under Child and Adolescent Mental Health Services (CAMHS) showed that those with neurodevelopmental disorders were the most affected, with worse emotional and behavioural change, but also more difficulties with complying with social distancing and engaging with online education (Parlatini et al., in preparation). Thus, pre-existing mental health conditions may negatively affect CYP's resilience and flexibility to adapt to rapid changes. Unfortunately, there is increasing concern, supported by the literature on previous outbreaks (Sprang & Silman, 2013), that the effects on mental health may become more apparent over time due to ongoing uncertainty, rapid changes in education access, family stress and reduced support from services. Further, having pre-existing mental health conditions has been identified as a risk factor for Long Covid in adults, and it is important to understand whether CYP with pre-existing mental health conditions may also be at higher risk, and how they may be affected by Long Covid. Finally, about one third of the surveyed families reported that CAMHS was not meeting their needs and it is not clear whether this was related to the transition from face-to-face to remote interventions. This also highlighted the necessity to develop an effective system to rapidly communicate individual survey results to clinicians, enabling effective follow-up and service planning. The importance of the pandemic and its ensuing restrictions on children's mental health is well-recognised; the UK inquiry on the Covid -18 pandemic and its handling has recently been extended specifically to include CYP's mental health. Helping clinicians understand which patients are at greatest risk; how they may be differentially affected by changes in social distancing restrictions and school provision over time; and whether the care provided meets their needs, is therefore pivotal to effectively respond to the current pandemic and to plan for any future scenarios.To understand how the different aspects of the pandemic, from social distancing to the effects on family economics and education, interplay with pre-Covid child-based factors (e.g. age, sex and diagnosis) and sociodemographic characteristics (e.g. ethnicity and family circumstances) and differentially impact on the mental health of CYP with pre-existing mental health conditions, by building a cross-sectional exploratory model of clinical outcome. To understand the effect of time-dependent factors, such as changes in social distancing restrictions and education provision as the pandemic evolves, by re-testing the sample at salient time points (e.g. school closure and re-opening) and modelling the trajectory of clinical outcomes over longitudinal data. To explore the potential mechanisms of change in outcomes during Covid-19 by conducting qualitative semi-structured interviews with CYP with pre-existing mental health conditions and their families.