BCD Research Infrastructure Enhancement Program

BCD 研究基础设施增强计划

• 批准号: 6951074
• 负责人: DAVID S. CARLSON
• 金额: $ 142.13万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951074
• 关键词: continuing education; cooperative study; craniofacial; dental personnel; dentistry; dentistry education; disease /disorder prevention /control; education evaluation /planning; growth /development; health science research support; postgraduate education; role model; teacher

DESCRIPTION (provided by applicant): The objective of the Infrastructure Improvement Grant is to strengthen the research infrastructure of Baylor College of Dentistry (BCD) by recruiting and developing outstanding faculty in tenure track positions and by developing the core infrastructure necessary to make this faculty successful with respect to basic, translational, and clinical research grants. These objectives will be accomplished through collaboration with the Institute of Biosciences and Technology (IBT) and leveraging of the federal funds through significant matching funds. A Critical Needs Assessment found that BCD has strengths with respect to basic science faculty, advanced clinical and Ph.D. programs, and research facilities, including a new Research Sciences Building that will come on-line in 2004 and 2005. However, BCD lacks a critical mass of successful research faculty and mentors in the basic sciences, especially in the areas of translational and clinical research, with sustained extramural grant funding. Based on a review of areas of strengths, it was decided that BCD should emphasize the research theme of developmental biology and genetics of the craniofacial complex, with special emphasis on the causes, prevention, and treatment of craniofacial deformities that might be expressed early in development and during the postnatal growth period. The Institutional Enhancement Plan is based primarily on formal collaboration with the IBT, and includes: (1) recruitment of Dr. Richard Finnell as a Magnet Investigator and four additional outstanding senior IBT scientists as research mentors; (2) recruitment of a new chair of the Department of Biomedical Sciences at BCD as a second Magnet Investigator; (3) recruitment of three junior faculty to BCD; and (4) comprehensive faculty exchanges. The Implementation Plan is already underway with recruitment of all IBT faculty and naming of the ESPAC. Detailed Letters of Institutional Commitment are provided from the President of the HSC, Dean of the Dental School, and the President of the Baylor Oral Health Foundation.

描述（由申请人提供）：基础设施改善补助金的目标是通过招聘和发展终身职位的优秀教师，并通过发展必要的核心基础设施，使该教师在基础，翻译和临床研究赠款方面取得成功，来加强贝勒牙科学院（BCD）的研究基础设施。这些目标将通过与生物科学和技术研究所（IBT）的合作以及通过重要的匹配资金利用联邦资金来实现。一项关键需求评估发现，BCD在基础科学教师、高级临床和博士方面具有优势。计划和研究设施，包括一个新的研究科学大楼，将在2004年和2005年上线。然而，BCD缺乏成功的研究教师和导师在基础科学，特别是在转化和临床研究领域的临界质量，与持续的校外赠款资金。根据对优势领域的审查，决定BCD应强调颅面复合体的发育生物学和遗传学的研究主题，特别强调可能在发育早期和出生后生长期间表达的颅面畸形的原因，预防和治疗。机构增强计划主要基于与IBT的正式合作，包括：（1）招聘Richard Finnell博士作为磁铁研究员，并招聘四名额外的优秀高级IBT科学家作为研究导师;（2）招聘生物医学科学系的新主席作为第二个磁铁研究员;（3）招聘三名初级教师到BCD;（4）招聘一名高级研究员。（4）全面的教师交流。实施计划已经在进行中，所有IBT教师的招聘和ESPAC的命名。详细的机构承诺书提供了从HSC的总裁，牙科学院院长，和贝勒口腔健康基金会的总裁。

项目成果

Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2.

黄体酮对内皮素-a 受体表达的控制通过与 Gata2 的协同作用得到增强。

• DOI: 10.1210/me.2012-1334
• 发表时间: 2013
• 期刊: Molecular endocrinology (Baltimore, Md.)
• 作者: Zhang,Yanping;Knutsen,GregoryR;Brown,MatthewD;Ruest,LBruno
• 通讯作者: Ruest,LBruno

Analysis of neural crest cell fate during cardiovascular development using Cre-activated lacZ/β-galactosidase staining.

使用 Cre 激活 lacZ/β-半乳糖苷酶染色分析心血管发育过程中的神经嵴细胞命运。

• DOI: 10.1007/978-1-61779-523-7_12
• 发表时间: 2012
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Zhang,Yanping;Ruest,LBruno
• 通讯作者: Ruest,LBruno

Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.

• DOI: 10.1002/dvdy.23776
• 发表时间: 2012-05
• 期刊: DEVELOPMENTAL DYNAMICS
• 影响因子: 2.5
• 作者: Zhang, Yanping;Blackwell, Evan L.;McKnight, Mitchell T.;Knutsen, Gregory R.;Vu, Wendy T.;Ruest, L. Bruno
• 通讯作者: Ruest, L. Bruno

Cleft lip and palate genetics and application in early embryological development.

唇腭裂遗传学及其在早期胚胎发育中的应用。

• DOI: 10.4103/0970-0358.57185
• 发表时间: 2009
• 期刊: Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
• 作者: Yu,Wenli;Serrano,Maria;Miguel,SymoneSan;Ruest,LBruno;Svoboda,KathyKH
• 通讯作者: Svoboda,KathyKH