BCD Research Infrastructure Enhancement Program

描述（由申请人提供）：基础设施改善资助的目标是通过招聘和培养终身教职的优秀教师，以及通过发展必要的核心基础设施，使这些教师在基础、转化和临床研究资助方面取得成功，来加强贝勒牙科学院（BCD）的研究基础设施。这些目标将通过与生物科学和技术研究所（IBT）的合作以及通过大量匹配基金撬杠杆联邦基金来实现。一项关键需求评估发现，BCD在基础科学师资、先进的临床和博士课程以及研究设施（包括将于2004年和2005年投入使用的新研究科学大楼）方面具有优势。然而，BCD在基础科学领域，特别是在转化和临床研究领域，缺乏足够数量的成功的研究教员和导师，缺乏持续的校外资助。基于对优势领域的回顾，决定BCD应强调颅面复合物的发育生物学和遗传学的研究主题，特别强调可能在发育早期和出生后生长期间表达的颅面畸形的原因，预防和治疗。机构加强计划主要基于与IBT的正式合作，包括：(1)招募Richard Finnell博士作为磁体调查员，另外四名杰出的IBT资深科学家作为研究导师；(2)招募BCD生物医学科学系新主任作为第二名磁体研究员；(3)为BCD招聘3名初级教师；(4)全面的教师交流。实施计划已经在进行中，包括招聘所有IBT教师和命名ESPAC。详细的机构承诺信由HSC主席、牙科学院院长和贝勒口腔健康基金会主席提供。

DESCRIPTION (provided by applicant): The objective of the Infrastructure Improvement Grant is to strengthen the research infrastructure of Baylor College of Dentistry (BCD) by recruiting and developing outstanding faculty in tenure track positions and by developing the core infrastructure necessary to make this faculty successful with respect to basic, translational, and clinical research grants. These objectives will be accomplished through collaboration with the Institute of Biosciences and Technology (IBT) and leveraging of the federal funds through significant matching funds. A Critical Needs Assessment found that BCD has strengths with respect to basic science faculty, advanced clinical and Ph.D. programs, and research facilities, including a new Research Sciences Building that will come on-line in 2004 and 2005. However, BCD lacks a critical mass of successful research faculty and mentors in the basic sciences, especially in the areas of translational and clinical research, with sustained extramural grant funding. Based on a review of areas of strengths, it was decided that BCD should emphasize the research theme of developmental biology and genetics of the craniofacial complex, with special emphasis on the causes, prevention, and treatment of craniofacial deformities that might be expressed early in development and during the postnatal growth period. The Institutional Enhancement Plan is based primarily on formal collaboration with the IBT, and includes: (1) recruitment of Dr. Richard Finnell as a Magnet Investigator and four additional outstanding senior IBT scientists as research mentors; (2) recruitment of a new chair of the Department of Biomedical Sciences at BCD as a second Magnet Investigator; (3) recruitment of three junior faculty to BCD; and (4) comprehensive faculty exchanges. The Implementation Plan is already underway with recruitment of all IBT faculty and naming of the ESPAC. Detailed Letters of Institutional Commitment are provided from the President of the HSC, Dean of the Dental School, and the President of the Baylor Oral Health Foundation.