Liquid chromatography for clinical silicon photonics

该博士项目旨在基于尖端的硅光子学研究开发一种用于临床诊断的新型传感器。在我们现有的中红外吸收光谱传感器中增加层析功能，将实现更强大的数据提取。这将为机器学习提供更多的信息，以提高临床决策的准确性。该项目将与我们在南安普顿大学医院(UHS)的合作伙伴一起探索这项技术的医学应用。一个例子是用于癌症诊断的液体活检，在这种方法中，这种方法可以改进对癌症和非癌症血液样本的区分，而不需要手术活检。该项目将通过设计、制造和测试传感器来监测生物标志物的独特光谱吸收指纹，以了解人体血液样本的组成，从而研究生物标志物的检测。微流控色谱将被开发用于与光子传感器的集成，以获得进一步的蛋白质组和脂组信息。

This PhD project aims to develop a new class of sensors for clinical diagnostics based on cutting- edge silicon photonics research. Adding the capability for chromatography to our existing sensors for mid-infrared absorption spectroscopy will enable more powerful data extraction. This will provide more information for machine learning to improve the accuracy of clinical decision-making.The project will explore medical applications for this technique with our partners at University Hospital Southampton (UHS). One example is liquid biopsy for cancer diagnostics in which this method can offer improved discrimination between cancerous and non-cancerous blood samples without the need for a surgical biopsy. The project will investigate detection of biomarkers by designing, fabricating and testing sensors for monitoring their unique spectral absorption fingerprints in order to understand the composition of human blood samples. Microfluidic chromatography will be developed for integration with the photonic sensors to obtain further proteomic and lipidomic information.