MOUSE GENETICS CORE

听力损失是人类最常见的感觉缺陷。在美国，大约每1000名新生儿中就有7名发生先天性、围产期或早发性听力损失。在50%的案例中，已知或怀疑是遗传贡献，老鼠和斑马鱼可用的强大分子和基因技术是研究听力生物学的有用模型系统。小鼠与人类听力的功能相似，使得小鼠成为临床上观察到的听力损失的一个特别有吸引力的模型。为了支持小鼠用户研究听觉系统功能，Core D将为用户提供专业的小鼠饲养(接收、设置杂交、断奶、饲养、背景转移等)、基因分型以及所需小鼠的通知/交付。按日收取的老鼠护理费用将由用户负责，前提是他们有一个资助项目，其中包括对老鼠笼费用的支持。为了鼓励创新和新的合作项目，我们将为共同控制动物和已批准的资助过渡项目提供每日支持。将定期审查核心D提供的所有服务，以确保质量和可及性。 Genetics Core将为各种用户提供服务。通过集中、专家的老鼠饲养和基因分型，将大大提高老鼠护理的效率。不精通老鼠护理的用户将获得大量已识别的基因敲除小鼠，并定义自发突变，以进一步开展他们的研究。有经验的鼠标用户将受益于Core员工对老鼠行为和护理的熟悉，为他们的品系提供更好的健康和更高的繁殖力。将向所有用户及其实验室人员提供畜牧业、基因分型和行为表征方面的培训。为了鼓励互动和新的合作，关于菌株、技术和项目的信息被 将在网上和遗传学核心用户会议上传播核心的所有用户所追求的信息。

Hearing loss is the most frequent sensory defect in humans. Congenital, perinatal or early onset hearing loss occurs in approximately 7 out of 1000 neonates in the United States. In 50% of these cases, a genetic contribution is known or suspected, the powerful molecular and genetic techniques available in mouse and zebra fish are useful model systems for studying the biology of hearing. The functional similarities between mouse and human audition make mouse a particularly attractive model for hearing loss observed clinically. In support of Users of mice to study auditory system function, Core D will provide expert mouse husbandry (receiving, setting up crosses, weaning, fostering, background transfers, etc), genotyping, and notification/delivery of requested mice to Users. Per diem charges for mouse care will be the responsibility of the User, provided that they have a funded project that includes support for mouse cage costs. To encourage innovative and new collaborative projects, we will provide per diem support for common control animals and for approved projects in funding transition. All services provided by Core D will be reviewed periodically to ensure quality and accessibility. The Genetics Core will provide services for a variety of Users. Efficiency of mouse care will be increased greatly by having centralized, expert mouse husbandry and genotyping. Users not proficient in mouse care will gain access the vast number of identified gene knockout mice and defined spontaneous mutants to further their research. Experienced mouse users will benefit from the familiarity of the Core staff with mouse behavior and care, providing better health and higher fecundity for their strains. Training in husbandry, genotyping, and behavioral characterization will be available to all Users and their lab personnel. To encourage interactions and new collaborations, information about the strains, techniques, and projects being pursued by all Users of the Core will be disseminated online and in Genetics Core User meetings.