Self-assembling matrixes to recreate the colorectal tumour niche (iCASE project with AZ)

自组装基质重建结直肠肿瘤生态位（与 AZ 合作的 iCASE 项目）

• 批准号: 2750177
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2750177
• 关键词: Self; assembling; matrixes; recreate; colorectal

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. This project aims to optimize an in vitro 3D organoid culture that would enable the study of the complexity of colorectal cancer and the effectiveness to drug response. To that end, we will use patient-derived organoids to optimize a novel peptide-based assembly platform that will represent a step-change in how putative anticancer drugs can be tested in vitro. In the long-term the outcome of this project may help to improve cancer patient's survival.

患者衍生的人类癌症体内模型已经成为现实，但其周转时间不足以用于临床应用。因此，迫切需要能够忠实概括体内肿瘤生物学的量身定制的离体模型。本项目旨在优化体外三维类器官培养，以研究结直肠癌的复杂性和药物反应的有效性。为此，我们将使用患者来源的类器官来优化一种新的基于肽的组装平台，这将代表着如何在体外测试假定的抗癌药物的一个步骤变化。从长远来看，这个项目的结果可能有助于提高癌症患者的生存率。