A Turnkey, Wireless, EEG/EMG/Biosensor Measurement

交钥匙无线脑电图/肌电图/生物传感器测量

• 批准号: 7054542
• 负责人: DAVID A JOHNSON
• 金额: $ 22.54万
• 依托单位: PINNACLE TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054542
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biosensor device; electroencephalography; electromyography; glucose metabolism; laboratory mouse; laboratory rat; portable biomedical equipment; sleep

DESCRIPTION (provided by applicant): The long term objective of this project is to develop, validate and commercialize wireless, head mounted, turnkey, EEG/EMG systems with an integrated biosensor for rats and mice. A further objective is to develop a 76 uM glucose biosensor for direct measurement of brain glucose levels in rats and mice. The specific aims of this Phase I project are to develop and test a 76 uM glucose biosensor, a tethered EEG/EMG/Biosensor solution for mice and a wireless solution for rats. To reach these objectives, Pinnacle Technology, Northwestern University and the University of Kansas are building on past successes in the design of glutamate biosensors, wireless potentiostats for rats, and tethered EEG/EMG systems for mice. These products were developed in separate collaborations and are currently being commercialized. Products to be introduced include: a tethered system for mice, a wireless system for rats, and ultimately a fully wireless system for mice. Commercial applications include sleep research, behavioral research and drug screening. Technological innovations include biosensor design, turnkey head mount design, advanced electronics design, and advanced low power radio frequency design. The ability to measure glucose from specific brain areas in vivo while simultaneously recording sleep in rodents will give researchers the ability to better examine the functioning of specific sites within the brain during the sleep process as well as leverage the advantages conferred by using rat and mouse models for research. At the moment, it is not possible to concurrently study sleep and glucose regulation in a mouse model and there is only one published account where it has been attempted in the rat. The ability to instantly record glucose levels in a sleeping mouse or rat, and correlate that activity with EEG/EMG, will be valuable to researchers studying sleep and metabolism. The investigation of glucose in a mouse model will open up new avenues of research with genetic mutations available in species such as the NIRKO mouse (brain/neuron-specific insulin receptor knockout) which may have altered glucose responses during sleep and provide clues as to how sleep and metabolism are linked.

描述（由申请人提供）：该项目的长期目标是开发，验证和商业化无线，头部安装，交钥匙，脑电图/EMG系统，具有用于大鼠和老鼠的集成生物传感器。一个进一步的目标是开发一个76 UM葡萄糖生物传感器，以直接测量大鼠和小鼠的脑葡萄糖水平。该阶段I项目的具体目的是开发和测试一个76 UM葡萄糖生物传感器，用于小鼠的束缚的EEG/EMG/生物传感器解决方案以及用于大鼠的无线溶液。为了达到这些目标，Pinnacle Technology，Northwestern University和堪萨斯大学正在建立谷氨酸生物传感器，大鼠的无线电位托机以及小鼠的束缚EEG/EMG系统。这些产品是在单独的合作中开发的，目前正在商业化。要引入的产品包括：小鼠的束缚系统，用于大鼠的无线系统以及最终用于小鼠的无线系统。商业应用包括睡眠研究，行为研究和药物筛查。技术创新包括生物传感器设计，交钥匙头架设计，高级电子设计和先进的低功率射频设计。同时在啮齿动物中同时记录睡眠的人体内特定大脑区域的葡萄糖的能力将使研究人员能够更好地检查睡眠过程中大脑内特定位点的功能，并利用使用大鼠和小鼠模型赋予研究的优势。目前，不可能在小鼠模型中同时研究睡眠和葡萄糖调节，只有一个已发表的帐户在大鼠中尝试过。能够立即记录沉睡的小鼠或大鼠葡萄糖水平并将其与脑电图/EMG相关的能力对于研究睡眠和代谢的研究人员很有价值。在小鼠模型中对葡萄糖的研究将开辟新的研究途径，其中诸如Nirko小鼠（脑/神经元特异性胰岛素受体敲除）中可用的遗传突变可能会改变睡眠过程中的葡萄糖反应，并提供有关睡眠和代谢如何联系起来的线索。