EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。耐力运动对健康生活很重要：它对长期控制体重至关重要，并与心血管疾病（CVD）的预防有关，可能是通过它降低血浆甘油三酯（TG）浓度的能力（无论是在禁食条件下还是饭后）。血浆TG浓度升高1,2（通常在肥胖人群中观察到）与心血管疾病（尤其是女性）之间存在直接关系4,5。根据美国心脏协会最近的一份报告，在美国和大多数发达国家，40%的女性死亡是由心血管疾病引起的，其中三分之一被认为是由于缺乏运动造成的。运动诱导血浆TG浓度降低的机制尚不清楚。然而，为了优化预防CVD的治疗方法，最终有必要了解控制血浆TG浓度的因素。此外，迄今为止，大多数试图探讨运动后血浆TG浓度降低的潜在机制的研究都是在精瘦的、经常受过训练的男性中进行的，而不是在肥胖的人和女性中进行的。我们（7-9）和其他人（10-11）发现，性别和肥胖都会影响脂质代谢，这使得对瘦人和男性的研究结果无法推广，并强调了专门针对女性和肥胖受试者的研究的重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endurance exercise is important fo a healthy life: it is essential for long term weight management and is involved in the prevention of cardiovascular disease (CVD), presumably via its ability to lower plasma triglyceride (TG) concentrations (both under fasted conditions and after a meal). There is a direct relationship between elevated plasma TG contrations, 1,2, which are commonly observed in obese persons3, and CVD, particularly in women 4,5. According to a recent report by the American Heart Association, >40% of female deaths in the US and most developed countries occur from CVD, one-third is thought to be attributable to inactivity6. The mechanisms that are responsible for the exercise-induced reduction in plasma TG concentrations are not known. In order to optimize therapies for the prevention of CVD, however, it is ultimately necessary to understand the factors that control plasma TG concentrations. Furthermore, most studies that sougth to investigate potential mechanism(s) for the decrease in plasma TG concentration in response to exercise to date have been performed in lean, oftentimes trained, men but not in obese persons and women. We 7-9, and others 10-11, found that both sex and adiposity affect lipik metabolism, which preludes the generalization of findings from lean subjects and men and underlines the importance of studies specifically targeted to women and obese subjects.