EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 耐力运动对健康生活很重要：它对长期体重管理至关重要，并参与预防心血管疾病（CVD），可能是通过其降低血浆甘油三酯（TG）浓度的能力（空腹条件下和餐后）。 在肥胖人群中常见的血浆TG浓度升高（1，2）与CVD（尤其是女性）之间存在直接关系（4，5）。 根据美国心脏协会最近的一份报告，在美国和大多数发达国家，>40%的女性死亡发生在CVD，三分之一被认为是由于不活动6。 运动引起的血浆TG浓度降低的机制尚不清楚。 然而，为了优化预防CVD的疗法，最终有必要了解控制血浆TG浓度的因素。 此外，迄今为止，大多数旨在研究运动后血浆TG浓度降低的潜在机制的研究都是在瘦的、经常接受训练的男性中进行的，而不是在肥胖的人和女性中进行的。 我们7-9和其他人10-11发现，性别和肥胖都会影响利皮克代谢，这预示着瘦受试者和男性的研究结果的普遍化，并强调了专门针对女性和肥胖受试者的研究的重要性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endurance exercise is important fo a healthy life: it is essential for long term weight management and is involved in the prevention of cardiovascular disease (CVD), presumably via its ability to lower plasma triglyceride (TG) concentrations (both under fasted conditions and after a meal). There is a direct relationship between elevated plasma TG contrations, 1,2, which are commonly observed in obese persons3, and CVD, particularly in women 4,5. According to a recent report by the American Heart Association, >40% of female deaths in the US and most developed countries occur from CVD, one-third is thought to be attributable to inactivity6. The mechanisms that are responsible for the exercise-induced reduction in plasma TG concentrations are not known. In order to optimize therapies for the prevention of CVD, however, it is ultimately necessary to understand the factors that control plasma TG concentrations. Furthermore, most studies that sougth to investigate potential mechanism(s) for the decrease in plasma TG concentration in response to exercise to date have been performed in lean, oftentimes trained, men but not in obese persons and women. We 7-9, and others 10-11, found that both sex and adiposity affect lipik metabolism, which preludes the generalization of findings from lean subjects and men and underlines the importance of studies specifically targeted to women and obese subjects.