AEROBIC EXERCISE AND PLASMA TRIGLYCERIDE CONCENTRATION

有氧运动和血浆甘油三酯浓度

基本信息

  • 批准号:
    7603359
  • 负责人:
  • 金额:
    $ 0.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-04-01 至 2007-09-16
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elevated postabsorptive and postprandial plasma triglyceride (TG) concentrations are associated with increased cardiovascular disease (CVD). This suggest that total plasma TG load (24-hour plasma TG concentration) is an important risk factor for CVD. Although exercise is associated with decreased CVD, its effect on plasma TG concentration and metabolism is not clear. 1) Data from studies investigating the effects of exercise on postabsorptive plasma TG concentration are conflicting. 2) There is good evidence that exercise lowers the rise in plasma TG concentration after consumption of a single high-fat test meal. However, the effects of exercise on postprandial plasma TG concentration after ingestion of a typical mixed meal are largely unknown, and the effects of exercise on 24-hour plasma TG concentration has never been studied. 3) The mechanisms responsible for the postprandial TG-lowering effect of exercise remain unclear. The primary objectives of this proposal are to evaluate the effects of exercise on 24-hour plasma TG concentration, and to determine potential metabolic mechanisms responsible for the exercise-induced changes in plasma TG concentration. We hypothesize that: 1) Exercise decreases total 24-hour plasma TG concentration, predominately by lowering plasma TG concentration after meals, 2) Exercise in the morning has a greater effect on total 24-hour plasma TG concentration than exercise performed in the evening, and 3) The exercise-induced decrease in postprandial plasma TG concentration is, at least in part, due to lower hepatic VLDL-TG secretion during postprandial hyperinsulinemia. To test our hypothesis we will measure plasma TG concentration every hour for 24 hours and measure hepatic VLDL-TG secretion (by using stable isotope labeled tracer techniques) during hyperinsulinemia in subjects with increased plasma TG concentrations after rest and exercise. The data generated from concenration the proposed studies will improve our understanding of the metabolic control of plasma TG concentration. Furthermore, they will help establish appropriate guidelines to lower plasma TG concentration via physical activity.
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。列出的机构为 研究中心,而研究中心不一定是研究者所在的机构。 吸收后和餐后血浆甘油三酯(TG)浓度升高与心血管疾病(CVD)增加相关。 这表明血浆总TG负荷(24小时血浆TG浓度)是CVD的重要危险因素。 虽然运动与降低心血管疾病有关,但其对血浆TG浓度和代谢的影响尚不清楚。 1)运动对吸收后血浆TG浓度影响的研究数据相互矛盾。 2)有很好的证据表明,运动降低了高脂餐后血浆TG浓度的上升。 然而,运动对摄入典型混合餐后餐后血浆TG浓度的影响在很大程度上是未知的,运动对24小时血浆TG浓度的影响从未被研究过。 3)运动对餐后TG降低作用的机制尚不清楚。 本研究的主要目的是评估运动对24小时血浆TG浓度的影响,并确定运动诱导血浆TG浓度变化的潜在代谢机制。 我们假设: 第一章 运动降低24小时总血浆TG浓度,主要通过降低餐后血浆TG浓度, (二) 早晨锻炼对24小时总血浆TG浓度的影响大于晚上锻炼, 第三章 运动诱导的餐后血浆TG浓度降低至少部分是由于餐后高胰岛素血症期间肝脏VLDL-TG分泌降低。 为了检验我们的假设,我们将在24小时内每小时测量一次血浆TG浓度,并在休息和运动后血浆TG浓度升高的受试者的高胰岛素血症期间测量肝脏VLDL-TG分泌(通过使用稳定同位素标记的示踪技术)。 从浓缩产生的数据,拟议的研究将提高我们的理解的代谢控制血浆TG浓度。 此外,他们将帮助建立适当的指导方针,通过体力活动降低血浆TG浓度。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Bettina Mittendorfer其他文献

Bettina Mittendorfer的其他文献

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{{ truncateString('Bettina Mittendorfer', 18)}}的其他基金

Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and Atherosclerosis
剖析膳食蛋白质对巨噬细胞 mTOR 信号传导和动脉粥样硬化的影响
  • 批准号:
    10446622
  • 财政年份:
    2022
  • 资助金额:
    $ 0.88万
  • 项目类别:
Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and Atherosclerosis
剖析膳食蛋白质对巨噬细胞 mTOR 信号传导和动脉粥样硬化的影响
  • 批准号:
    10809375
  • 财政年份:
    2022
  • 资助金额:
    $ 0.88万
  • 项目类别:
Harnessing macrophage lysosomal lipid metabolism in obesity-associated diseases
利用巨噬细胞溶酶体脂质代谢治疗肥胖相关疾病
  • 批准号:
    10658896
  • 财政年份:
    2022
  • 资助金额:
    $ 0.88万
  • 项目类别:
OSA and Glucose Metabolism
OSA 和葡萄糖代谢
  • 批准号:
    10228575
  • 财政年份:
    2017
  • 资助金额:
    $ 0.88万
  • 项目类别:
OSA AND GLUCOSE METABOLISM
OSA 和葡萄糖代谢
  • 批准号:
    9424214
  • 财政年份:
    2017
  • 资助金额:
    $ 0.88万
  • 项目类别:
Clinical Science Research Core
临床科学研究核心
  • 批准号:
    8132690
  • 财政年份:
    2011
  • 资助金额:
    $ 0.88万
  • 项目类别:
EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM
耐力运动对 VLDL-TG 代谢的影响
  • 批准号:
    7603320
  • 财政年份:
    2007
  • 资助金额:
    $ 0.88万
  • 项目类别:
AEROBIC EXERCISE AND PLASMA TRIGLYCERIDE CONCENTRATION
有氧运动和血浆甘油三酯浓度
  • 批准号:
    7377246
  • 财政年份:
    2006
  • 资助金额:
    $ 0.88万
  • 项目类别:
EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM
耐力运动对 VLDL-TG 代谢的影响
  • 批准号:
    7377197
  • 财政年份:
    2006
  • 资助金额:
    $ 0.88万
  • 项目类别:
EFFECT OF ENDURANCE EXERCISE ON VLDL-TG METABOLISM
耐力运动对 VLDL-TG 代谢的影响
  • 批准号:
    7198709
  • 财政年份:
    2005
  • 资助金额:
    $ 0.88万
  • 项目类别:

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