ANCESTRAL ADMIXTURE AND INSULIN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。非裔美国人(AA)和墨西哥裔美国人(MA)的糖尿病患病率高于欧洲裔美国人(EA)。这项研究旨在调查不同种族的儿童。首先，通过研究这个样本，我们将在许多环境和行为因素对疾病风险产生影响之前，观察早期的病理生理因素。此外，了解儿童糖尿病相关特征的病因将有助于在生命早期制定干预策略，从而加强疾病预防。这项研究的主要目的是调查遗传和环境参数对胰岛素分泌和作用方面的种族/民族差异的影响。需要检验的具体假设是：1)较低的欧洲混合胰岛素(ADM)水平与较高的空腹胰岛素、较低的胰岛素敏感性(SI)和较高的急性胰岛素对葡萄糖的反应(AIR G)相关；2)在较低的欧洲ADM水平的儿童中，较低的体力活动水平将部分解释较低的SI水平以及较高的空腹胰岛素和AIR G水平；在较低的欧洲ADM水平的儿童中，食物摄入量和社会经济地位(SES)都不会对空腹胰岛素、SI和AIR G的测量产生影响；3)由祖先信息标记代表的基因组中的DNA序列将与空腹胰岛素、Si和airG显著相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of diabetes is higher among African-Americans (AA) and Mexican Americans (MA) vs European Americans (EA). This study has been designed to investigate children of different racial groups. First, by studying this sample we will be looking at the early pathophysiological factors, before many environmental and behavioral factors exert an influence in disease risk. In addition, understanding the etiology of diabetes-related traits in children will allow the development of intervention strategies at early stages of life that will increase disease prevention. The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in aspects of insulin secretion and action. The specific hypotheses to be tested are that, 1) Lower levels of European admixture (ADM) are associated with higher fasting insulin, lower insulin sensitivity (Si), and higher acute insulin response to glucose (AIRg); 2) In children with lower levels of European ADM, lower levels of physical activity will explain, in part, lower levels of Si and higher levels of fasting insulin and AIRg; in children with lower levels of European ADM, neither food intake nor socioeconomic status (SES) will have an effect on measures of fasting insulin, Si and AIRg; 3) Sequences of DNA across the genome represented by ancestry informative markers will be significantly associated with fasting insulin, Si, and AIRg.