Admixture Mapping for Insulin Complex Outcomes

胰岛素复合结果的混合图

• 批准号: 7276933
• 负责人: JOSE R FERNANDEZ
• 金额: $ 8.09万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276933
• 关键词: African American; Hispanic Americans; body composition; carbohydrate balance; caucasian American; clinical research; diabetes mellitus; disease /disorder model; gel electrophoresis; genetic mapping; genetic markers; glucose tolerance; glucose tolerance test; human subject; insulin sensitivity /resistance; interview; middle childhood (6-11); nutrition related tag; photon absorptiometry; questionnaires; racial /ethnic difference; socioeconomics

DESCRIPTION (provided by applicant): Racial and ethnic differences in the incidence of diabetes have been identified in epidemiological studies. Although recent investigations have associated genetic markers and environmental factors contributing to the diabetes-related phenotypes within populations, the extent to which these factors in fact account for racial/ethnic differences is still unclear. The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in diabetes-related traits by modeling individual estimates of genetic admixture and environmental measures of energy intake, energy expenditure and socioeconomic status (SES) on measures of fasting insulin, sensitivity to insulin and initial phase of insulin secretion after exposure to glucose. A sample of 120 African-American (AA), 120 European-American (EA) and 120 Hispanic-American (HA) boys and girls of 7-13 years of age will be tested to obtain outcomes of insulin action and response, body composition, energy intake and energy expenditure to questionnaire and SES. The specific aims of this investigation are: (a) To test the role of European genetic admixture on diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg) after adjusted for body composition parameters (2) To investigate how the relationship between the environmental parameters energy intake, energy expenditure and socioeconomic status differ as a function of admixture and diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg), and (3) To test phenotype-genotype associations between ancestry-informative markers (AIMs) and measures of FG, Si and AIRg after adjusted for body composition and environmental parameters in a sample of AA, HA and EA prepubertal children. The proposed investigation will provide meaningful and important insight into the understanding of biological, non-biological and the interaction of both components in racial/ethnic differences in diabetes-related traits. Furthermore, the results of this investigation will serve as a tool for the development of effective preventive strategies to reduce the prevalence of diabetes and its related traits in racial/ethnic populations.

描述(由申请人提供)：流行病学研究已确定糖尿病发病率的种族和民族差异。虽然最近的研究已经发现遗传标记和环境因素与人群中糖尿病相关的表型有关，但这些因素实际上在多大程度上解释了种族/民族差异仍不清楚。这项研究的主要目的是通过模拟个体对遗传混合的估计以及环境测量的能量摄入、能量消耗和社会经济地位(SES)来研究遗传和环境参数对糖尿病相关特征的种族/民族差异的影响。 对120名非洲裔美国人(AA)、120名欧洲裔美国人(EA)和120名西班牙裔美国人(HA)7-13岁的男孩和女孩进行测试，以获得调查问卷和SES的胰岛素作用和反应、身体成分、能量摄入和能量消耗的结果。这项研究的具体目的是：(A)测试欧洲混合基因在调整身体成分参数后对糖尿病相关的空腹胰岛素(FI)、胰岛素敏感性(Si)和胰岛素对葡萄糖的反应(AirG)的作用；(2)调查环境参数能量摄入、能量消耗和社会经济地位之间的关系如何随着混合剂和糖尿病相关的空腹胰岛素(FI)、胰岛素敏感性(Si)和胰岛素对血糖(AirG)的测量而变化，以及(3)测试祖先信息标记(AIMS)和FG的测量之间的表型-基因相关性。在对AA、HA和EA青春期前儿童的身体成分和环境参数进行调整后，SI和airG。拟议的调查将为理解糖尿病相关特征的种族/民族差异中的生物学和非生物学以及这两个组成部分的相互作用提供有意义和重要的见解。此外，这项调查的结果将作为制定有效预防战略的工具，以减少糖尿病及其相关特征在种族/民族人口中的患病率。