Admixture Mapping for Insulin Complex Outcomes

胰岛素复合结果的混合图

• 批准号: 7687071
• 负责人: JOSE R FERNANDEZ
• 金额: $ 6.38万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7687071
• 关键词: Accounting; Acute; Admixture; African American; Age-Years; American; Area; Biological; Blood; Body Composition; Characteristics; Child; Chromosomes, Human, Pair 1; Classification; Complex; Condition; DNA Sequence; Data; Development; Diabetes Mellitus; Disease; Eating; Energy Intake; Energy Metabolism; Environment; Environmental Risk Factor; Epidemiologic Studies; Ethnic group; European; Evolution; Exposure to; Fasting; Female; Future; Genes; Genetic; Genetic Markers; Genome; Genotype; Glucose; Hispanic Americans; Hour; Human; Incidence; Individual; Insulin; Intervention; Investigation; Maps; Measures; Metabolic syndrome; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outcome Measure; Phase; Phenotype; Physical activity; Population; Predisposition; Prevalence; Prevention strategy; Principal Investigator; Proxy; Puberty; Questionnaires; Race; Reporting; Risk; Risk Factors; Role; Sampling; Socioeconomic Status; Testing; Variant; boys; diabetes risk; diabetic; girls; insight; insulin secretion; insulin sensitivity; preference; prevent; racial and ethnic; racial difference; racial/ethnic difference; response; tool development; trait

DESCRIPTION (provided by applicant): Racial and ethnic differences in the incidence of diabetes have been identified in epidemiological studies. Although recent investigations have associated genetic markers and environmental factors contributing to the diabetes-related phenotypes within populations, the extent to which these factors in fact account for racial/ethnic differences is still unclear. The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in diabetes-related traits by modeling individual estimates of genetic admixture and environmental measures of energy intake, energy expenditure and socioeconomic status (SES) on measures of fasting insulin, sensitivity to insulin and initial phase of insulin secretion after exposure to glucose. A sample of 120 African-American (AA), 120 European-American (EA) and 120 Hispanic-American (HA) boys and girls of 7-13 years of age will be tested to obtain outcomes of insulin action and response, body composition, energy intake and energy expenditure to questionnaire and SES. The specific aims of this investigation are: (a) To test the role of European genetic admixture on diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg) after adjusted for body composition parameters (2) To investigate how the relationship between the environmental parameters energy intake, energy expenditure and socioeconomic status differ as a function of admixture and diabetes-related measures of fasting insulin (FI), insulin sensitivity (Si) and insulin response to glucose (AIRg), and (3) To test phenotype-genotype associations between ancestry-informative markers (AIMs) and measures of FG, Si and AIRg after adjusted for body composition and environmental parameters in a sample of AA, HA and EA prepubertal children. The proposed investigation will provide meaningful and important insight into the understanding of biological, non-biological and the interaction of both components in racial/ethnic differences in diabetes-related traits. Furthermore, the results of this investigation will serve as a tool for the development of effective preventive strategies to reduce the prevalence of diabetes and its related traits in racial/ethnic populations.

描述（由申请人提供）：流行病学研究已经确定了糖尿病发病率的种族和民族差异。尽管最近的研究将遗传标记和环境因素与人群中糖尿病相关表型相关，但这些因素实际上在多大程度上解释了种族/民族差异仍不清楚。本研究的主要目的是通过对遗传混合的个体估计和能量摄入、能量消耗和社会经济地位（SES）的环境测量对空腹胰岛素、胰岛素敏感性和暴露于葡萄糖后胰岛素分泌初始阶段的测量进行建模，研究遗传和环境参数对糖尿病相关性状的种族/民族差异的影响。 将对 120 名非裔美国人 (AA)、120 名欧洲裔美国人 (EA) 和 120 名西班牙裔美国人 (HA) 7-13 岁的男孩和女孩进行测试，以获得胰岛素作用和反应、身体成分、能量摄入和能量消耗的问卷调查和 SES 结果。本研究的具体目的是： (a) 在调整身体成分参数后，测试欧洲基因混合物对糖尿病相关的空腹胰岛素 (FI)、胰岛素敏感性 (Si) 和胰岛素对葡萄糖的反应 (AIRg) 测量的作用 (2) 研究环境参数能量摄入、能量消耗和社会经济状况之间的关系如何作为混合物和社会经济状况的函数而变化。 与糖尿病相关的空腹胰岛素 (FI)、胰岛素敏感性 (Si) 和胰岛素对葡萄糖反应 (AIRg) 的测量，以及 (3) 在 AA、HA 和 EA 青春期前儿童样本中调整身体成分和环境参数后，测试祖先信息标记 (AIM) 与 FG、Si 和 AIRg 测量之间的表型-基因型关联。拟议的研究将为理解糖尿病相关特征的种族/民族差异中的生物、非生物以及这两种成分的相互作用提供有意义且重要的见解。此外，这项调查的结果将作为制定有效预防策略的工具，以减少种族/族裔人群中糖尿病及其相关特征的患病率。