EFFECT OF GASTRIC BYPASS ON ADIPONECTIN LEVELS AND INSULIN RESISTANCE

胃绕道术对脂联素水平和胰岛素抵抗的影响

• 批准号: 7374614
• 负责人: DARA P SCHUSTER
• 金额: $ 0.46万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374614
• 关键词: EFFECT; GASTRIC; BYPASS; ADIPONECTIN; LEVELS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of obesity is rising dramatically. As the number of obese people increases, so do the complications associated with obesity. In recent years it has been discovered that adipose tissue plays a key role in the pathogenesis of obesity and T2DM. Adiponectin is an adipocytokine that may be one of the key contributors. This study hopes to evaluate adiponectin levels and insulin resistance in both AA and CA with T2DM before and after gastric bypass surgery. This will be accomplished by measuring adiponectin, glucose, CRP, HbA1c, IL-6 and TNF-alpha levels in subjects before and after gastric bypass surgery. Homeostasis model assessment (HOMA) insulin resistance (IR) will be determined. The HOMA -IR is a formula used to approximate insulin resistance. Forty-five subjects, 10 African American (AA) and 35 Caucasian American (CA) subjects, will be recruited. Informed consent will be obtained. The presence of significant ethnic differences in adiponectin levels may be one of the reasons that complications of T2DM vary between AA and CA. Furthermore, differences in adiponectin levels and insulin resistance before and after gastric bypass may help determine which patients are most likely to benefit from gastric bypass surgery.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。肥胖症的患病率正在急剧上升。随着肥胖人数的增加，与肥胖相关的并发症也在增加。近年来，人们发现脂肪组织在肥胖和T2 DM的发病机制中起着关键作用。脂联素是一种脂肪细胞因子，可能是其中的关键因素之一。本研究希望评估AA和CA合并T2 DM患者胃旁路手术前后的脂联素水平和胰岛素抵抗情况。这将通过检测胃旁路手术前后受试者的脂联素、血糖、C反应蛋白、糖化血红蛋白、IL-6和肿瘤坏死因子-α水平来实现。将确定稳态模型评估(HOMA)、胰岛素抵抗(IR)。HOMA-IR是一种用来近似胰岛素抵抗的公式。将招募45名受试者，10名非裔美国人(AA)和35名高加索美国人(CA)。将获得知情同意。脂联素水平存在显著的种族差异可能是2型糖尿病并发症在AA和CA之间存在差异的原因之一。此外，胃旁路手术前后脂联素水平和胰岛素抵抗的差异可能有助于确定哪些患者最有可能从胃旁路手术中受益。