EFFECT OF GASTRIC BYPASS ON ADIPONECTIN LEVELS AND INSULIN RESISTANCE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肥胖症的流行率正在急剧上升。 随着肥胖人数的增加，与肥胖相关的并发症也在增加。 近年来发现脂肪组织在肥胖和T2 DM的发病机制中起关键作用。 脂联素是一种脂肪细胞因子，可能是其中一个关键因素。 本研究旨在评估2型糖尿病AA和CA患者胃旁路手术前后的脂联素水平和胰岛素抵抗。 这将通过测量胃旁路手术前后受试者的脂联素、葡萄糖、CRP、HbA 1c、IL-6和TNF-α水平来完成。 将测定稳态模型评估（HOMA）胰岛素抵抗（IR）。 HOMA-IR是用于近似胰岛素抵抗的公式。 将招募45例受试者，包括10例非洲裔美国人（AA）和35例高加索裔美国人（CA）受试者。 将获得知情同意。 脂联素水平存在显著种族差异可能是AA和CA之间T2 DM并发症不同的原因之一。 此外，胃旁路手术前后脂联素水平和胰岛素抵抗的差异可能有助于确定哪些患者最有可能从胃旁路手术中获益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of obesity is rising dramatically. As the number of obese people increases, so do the complications associated with obesity. In recent years it has been discovered that adipose tissue plays a key role in the pathogenesis of obesity and T2DM. Adiponectin is an adipocytokine that may be one of the key contributors. This study hopes to evaluate adiponectin levels and insulin resistance in both AA and CA with T2DM before and after gastric bypass surgery. This will be accomplished by measuring adiponectin, glucose, CRP, HbA1c, IL-6 and TNF-alpha levels in subjects before and after gastric bypass surgery. Homeostasis model assessment (HOMA) insulin resistance (IR) will be determined. The HOMA -IR is a formula used to approximate insulin resistance. Forty-five subjects, 10 African American (AA) and 35 Caucasian American (CA) subjects, will be recruited. Informed consent will be obtained. The presence of significant ethnic differences in adiponectin levels may be one of the reasons that complications of T2DM vary between AA and CA. Furthermore, differences in adiponectin levels and insulin resistance before and after gastric bypass may help determine which patients are most likely to benefit from gastric bypass surgery.