EFFECT OF GASTRIC BYPASS ON ADIPONECTIN LEVELS AND INSULIN RESISTANCE

胃绕道术对脂联素水平和胰岛素抵抗的影响

• 批准号: 7625458
• 负责人: DARA P SCHUSTER
• 金额: $ 2.53万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625458
• 关键词: Adipose tissue; African American; American; Computer Retrieval of Information on Scientific Projects Database; Funding; Gastric Bypass; Glucose; Glycosylated hemoglobin A; Grant; Homeostasis; Informed Consent; Institution; Insulin Resistance; Interleukin-6; Measures; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Numbers; Obesity; Pathogenesis; Patients; Play; Prevalence; Recruitment Activity; Research; Research Personnel; Resources; Role; Source; Tumor Necrosis Factor-alpha; United States National Institutes of Health; adiponectin; bariatric surgery; caucasian American; cysteine rich protein; ethnic difference; human TNF protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of obesity is rising dramatically. As the number of obese people increases, so do the complications associated with obesity. In recent years it has been discovered that adipose tissue plays a key role in the pathogenesis of obesity and T2DM. Adiponectin is an adipocytokine that may be one of the key contributors. This study hopes to evaluate adiponectin levels and insulin resistance in both AA and CA with T2DM before and after gastric bypass surgery. This will be accomplished by measuring adiponectin, glucose, CRP, HbA1c, IL-6 and TNF-alpha levels in subjects before and after gastric bypass surgery. Homeostasis model assessment (HOMA) insulin resistance (IR) will be determined. The HOMA -IR is a formula used to approximate insulin resistance. Forty-five subjects, 10 African American (AA) and 35 Caucasian American (CA) subjects, will be recruited. Informed consent will be obtained. The presence of significant ethnic differences in adiponectin levels may be one of the reasons that complications of T2DM vary between AA and CA. Furthermore, differences in adiponectin levels and insulin resistance before and after gastric bypass may help determine which patients are most likely to benefit from gastric bypass surgery.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 肥胖的患病率急剧上升。 随着肥胖人数的增加，与肥胖相关的并发症也会增加。 近年来，人们发现脂肪组织在肥胖和T2DM的发病机理中起关键作用。 脂联素是一种脂肪细胞因子，可能是关键因素之一。 这项研究希望通过T2DM在胃旁路手术前后评估AA和CA的脂联素水平和胰岛素抵抗。 这将通过测量胃旁路手术前后的受试者中测量脂联素，葡萄糖，CRP，HBA1C，IL-6和TNF-Alpha水平来实现。 将确定稳态模型评估（HOMA）胰岛素抵抗（IR）。 HOMA -IR是用于近似胰岛素抵抗的公式。 将招募45名主题，10名非裔美国人（AA）和35名高加索人（CA）主题。 将获得知情同意。 脂联素水平上存在重大种族差异可能是T2DM并发症在AA和CA之间变化的原因之一。 此外，胃搭桥前后的脂联素水平和胰岛素抵抗的差异可能有助于确定哪些患者最有可能受益于胃搭桥手术。