Relationship of Frailty to Multimorbidity and Disability

虚弱与多种疾病和残疾的关系

• 批准号: 7056384
• 负责人: CHRISTINE T CIGOLLE
• 金额: $ 5.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056384
• 关键词: behavioral /social science research tag; comorbidity; disabling disease; frail elderly; functional ability; health care service utilization; health services research tag; human data; human old age (65+); patient oriented research; postdoctoral investigator

DESCRIPTION (provided by applicant): The overall goal of the proposed research is to use nationally representative health interview survey data, the 2004 wave of the Health and Retirement Study (HRS), to investigate frailty in older adults. Using physical performance measures newly available in the HRS, the research will operationalize the frailty phenotype developed by Fried et al. The research will then compare the Fried model to other models of frailty; examine the association of frailty with other defining clinical characteristics of older adults (multimorbidity, cognitive impairment, disability); and examine utilization patterns and cost outcomes associated with these characteristics. The proposed research will evaluate three hypotheses: (1) the prevalence of frailty in the HRS is similar to that in the Cardiovascular Health Study (CHS), the population sample in which the Fried frailty phenotype was first operationalized. (2) Self-report measures may substitute for performance measures as frailty-defining criteria. (3) Although the frail population overlaps with populations with multimorbidity and with disability, nonetheless, the three are distinct, with distinct health care utilization patterns and costs. The proposed research will be an initial step to a more comprehensive study that will incorporate linked Medicare claims data and longitudinal survey data.

描述（由申请人提供）：拟议研究的总体目标是使用具有全国代表性的健康访谈调查数据，即2004年的健康与退休研究（HRS），以调查老年人的脆弱性。使用HRS中新提供的身体表现指标，该研究将操作化Fried等人开发的虚弱表型。然后，该研究将Fried模型与其他虚弱模型进行比较;检查虚弱与老年人其他定义临床特征（多发性硬化、认知障碍、残疾）的相关性;并检查与这些特征相关的利用模式和成本结果。拟议的研究将评估三个假设：（1）HRS中虚弱的患病率与心血管健康研究（CHS）中的患病率相似，CHS是首次实施Fried虚弱表型的人群样本。(2)自我报告的措施可以取代性能指标作为脆弱性定义标准。(3)尽管体弱人群与多重残疾人群和残疾人群重叠，但这三者是不同的，具有不同的保健利用模式和费用。拟议的研究将是一个更全面的研究，将结合相关的医疗保险索赔数据和纵向调查数据的第一步。