Chronic Ethanol Consumption, Opioids and Dopamine

慢性乙醇消耗、阿片类药物和多巴胺

• 批准号: 7168858
• 负责人: Brendan M Walker
• 金额: $ 4.88万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-07 至 2007-01-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168858
• 关键词: alcoholism /alcohol abuse; amygdala; behavior test; dopamine; drug habituation; drug withdrawal; endogenous opioid; laboratory rat; neurochemistry; operant conditionings; opioid receptor; pharmacokinetics; postdoctoral investigator; psychopharmacology; reinforcer

DESCRIPTION (provided by applicant): Due to evidence suggesting that brain reinforcement systems are engaging in allostatic processes to combat the chronic effects of ethanol administration, the present series of experiments are designed to identify changes in basal and ethanol administration-contingent endogenous opioid and dopamine levels in the rat brain during acute and protracted withdrawal in ethanol dependent and non-dependent animals. Furthermore, non-selective and selective opioid receptor antagonists/agonists will be used to pharmacologically study the role of opioids within specific regions of the extended amygdala during acute withdrawal in ethanol dependent and non-dependent rats. These series of experiments will help to classify allostatic changes in brain reinforement systems that could contribute to addiction and dependence and possibly help to identify appropriate pharmacotherapeutics for use in the treatment of alcoholism.

描述（由申请人提供）：由于有证据表明脑强化系统参与了对抗乙醇给药慢性效应的变应性过程，本系列实验旨在确定乙醇依赖性和非依赖性动物急性和长期戒断期间大鼠脑中基础和乙醇给药相关内源性阿片样物质和多巴胺水平的变化。 此外，将使用非选择性和选择性阿片受体拮抗剂/激动剂，在乙醇依赖性和非依赖性大鼠急性戒断期间，对阿片类药物在扩展杏仁核特定区域内的作用进行初步研究。这一系列的实验将有助于对大脑强化系统中可能导致成瘾和依赖的变应性变化进行分类，并可能有助于确定用于治疗酒精中毒的适当药物治疗。

项目成果

The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats.

γ-氨基丁酸-B 受体激动剂巴氯芬可减弱乙醇依赖大鼠对乙醇的反应。

• DOI: 10.1111/j.1530-0277.2006.00259.x
• 发表时间: 2007
• 期刊: Alcoholism, clinical and experimental research
• 作者: Walker,BrendanM;Koob,GeorgeF
• 通讯作者: Koob,GeorgeF

Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake".

关于“强啡肽是纹状体 BDNF 调节乙醇摄入量的下游效应器”。

• DOI: 10.1096/fj.08-0702ltr
• 发表时间: 2008
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Walker,BrendanM;Koob,GeorgeF
• 通讯作者: Koob,GeorgeF