Determinants of Midlife & Longitudinal Change in Cognitive Function: CARDIA Study

中年的决定因素

• 批准号: 8963476
• 负责人: Stephen Sidney
• 金额: $ 75.72万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8963476
• 关键词: Address; Adult; Age; Alzheimer' s Disease; Ancillary Study; Behavioral; Blood Pressure; Blood Vessels; Brain; Brain region; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Pathways; Cognition; Cognitive aging; Coronary Artery Risk Development in Young Adults Study; Coronary artery; Data; Dementia; Development; Diabetes Mellitus; Diet; Dyslipidemias; Elderly; Exposure to; Foundations; Future; Genetic; Genetic Risk; Health; Impaired cognition; Inflammation; Insulin; Investigation; Life; Life Cycle Stages; Life Style; Longitudinal Studies; Magnetic Resonance Imaging; Maintenance; Measures; Mental Depression; Metabolic; Modification; Obesity; Onset of illness; Outcome; Participant; Physical activity; Positioning Attribute; Preventive Intervention; Process; Prospective Studies; Research; Risk; Risk Factors; Science; Social support; United States; United States National Institutes of Health; Vascular Dementia; Visit; Woman; aged; aging brain; cognitive ability; cognitive change; cognitive function; cognitive testing; cohort; early life exposure; emerging adult; follow-up; genetic risk factor; genetic variant; genome-wide; innovation; lifestyle factors; men; middle age; modifiable risk; prevent; public health relevance; young adult

DESCRIPTION (provided by applicant): Almost nothing is known about how exposure to key risk factors in early life influences cognitive function and its decline later in life. Evidence suggests that the neuropathologic process leading to dementia, especially Alzheimer disease and vascular dementia, begins decades before clinical features become apparent. Recent research has convincingly demonstrated that mid-life risk factors, especially those related to cardiovascular disease and lifestyle factors, have a substantial impact on later life cognition. However, much less is known about earlier, e.g. young adult, risk factors and their effect on cognition in mid-life and later. We propose to address this gap by conducting an innovative ancillary study to the ongoing CARDIA study. CARDIA is a multisite prospective study of 5,115 black and white adults, aged 18-30 years at baseline (1985-86), who recently completed their seventh (year 25) follow-up in which cognitive testing and brain MRIs were measured and who will be participating in a year 30 exam in 2015-16. We propose to repeat and augment the cognitive testing for the year 30 visit on an estimated 3100 participants. In the first study of it kind in the United States, we propose to estimate 30-year trajectories of key vascular, metabolic and lifestyle factors, and quantify brain region volumes by MRI to assess their relationship to level and change in cognition in adulthood. In addition, we will use already collected genome-wide genetic data to investigate the association of genetic variants, which are known to influence these risk factors and brain MRI outcomes, with cognition. Completion of the scientific aims will help determine when cognitive changes begin to occur in mid-life and the use of a life course approach will allows us to study long-term exposure, from early life onward, in hopes of studying the potential effect of risk factor modification. The proposal has great

描述（由申请人提供）：对于生命早期接触关键风险因素如何影响认知功能及其晚年衰退几乎一无所知。有证据表明，导致痴呆（尤其是阿尔茨海默病和血管性痴呆）的神经病理过程在临床特征变得明显之前几十年就开始了。最近的研究令人信服地证明，中年危险因素，特别是与心血管疾病和生活方式因素相关的因素，对晚年认知产生重大影响。然而，人们对早期的情况知之甚少，例如年轻人、危险因素及其对中年及以后认知的影响。我们建议通过对正在进行的 CARDIA 研究进行创新性辅助研究来解决这一差距。 CARDIA 是一项多中心前瞻性研究，对象为 5,115 名黑人和白人成年人，基线年龄（1985-86 年）年龄为 18-30 岁，他们最近完成了第七次（25 岁）随访，其中测量了认知测试和脑部 MRI，并将参加 2015-16 年的 30 岁检查。我们建议对第 30 年访问的估计 3100 名参与者重复并增强认知测试。在美国的第一项此类研究中，我们建议估计关键血管、代谢和生活方式因素的 30 年轨迹，并通过 MRI 量化大脑区域体积，以评估它们与成年期认知水平和变化的关系。此外，我们将使用已经收集的全基因组遗传数据来研究遗传变异与认知的关联，已知遗传变异会影响这些危险因素和脑部 MRI 结果。科学目标的完成将有助于确定中年认知变化何时开始发生，而生命历程方法的使用将使我们能够研究从生命早期开始的长期暴露，希望研究危险因素修正的潜在影响。该提案有很大的