Determinants of Midlife & Longitudinal Change in Cognitive Function: CARDIA Study

中年的决定因素

基本信息

批准号：
8963476
负责人：
Stephen Sidney
金额：
$ 75.72万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-01 至 2018-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8963476
关键词：
Address Adult Age Alzheimer&apos s Disease Ancillary Study Behavioral Blood Pressure Blood Vessels Brain Brain region Cardiovascular Diseases Cardiovascular system Clinical Clinical Pathways Cognition Cognitive aging Coronary Artery Risk Development in Young Adults Study Coronary artery Data Dementia Development Diabetes Mellitus Diet Dyslipidemias Elderly Exposure to Foundations Future Genetic Genetic Risk Health Impaired cognition Inflammation Insulin Investigation Life Life Cycle Stages Life Style Longitudinal Studies Magnetic Resonance Imaging Maintenance Measures Mental Depression Metabolic Modification Obesity Onset of illness Outcome Participant Physical activity Positioning Attribute Preventive Intervention Process Prospective Studies Research Risk Risk Factors Science Social support United States United States National Institutes of Health Vascular Dementia Visit Woman aged aging brain cognitive ability cognitive change cognitive function cognitive testing cohort early life exposure emerging adult follow-up genetic risk factor genetic variant genome-wide innovation lifestyle factors men middle age modifiable risk prevent public health relevance young adult

项目摘要

DESCRIPTION (provided by applicant): Almost nothing is known about how exposure to key risk factors in early life influences cognitive function and its decline later in life. Evidence suggests that the neuropathologic process leading to dementia, especially Alzheimer disease and vascular dementia, begins decades before clinical features become apparent. Recent research has convincingly demonstrated that mid-life risk factors, especially those related to cardiovascular disease and lifestyle factors, have a substantial impact on later life cognition. However, much less is known about earlier, e.g. young adult, risk factors and their effect on cognition in mid-life and later. We propose to address this gap by conducting an innovative ancillary study to the ongoing CARDIA study. CARDIA is a multisite prospective study of 5,115 black and white adults, aged 18-30 years at baseline (1985-86), who recently completed their seventh (year 25) follow-up in which cognitive testing and brain MRIs were measured and who will be participating in a year 30 exam in 2015-16. We propose to repeat and augment the cognitive testing for the year 30 visit on an estimated 3100 participants. In the first study of it kind in the United States, we propose to estimate 30-year trajectories of key vascular, metabolic and lifestyle factors, and quantify brain region volumes by MRI to assess their relationship to level and change in cognition in adulthood. In addition, we will use already collected genome-wide genetic data to investigate the association of genetic variants, which are known to influence these risk factors and brain MRI outcomes, with cognition. Completion of the scientific aims will help determine when cognitive changes begin to occur in mid-life and the use of a life course approach will allows us to study long-term exposure, from early life onward, in hopes of studying the potential effect of risk factor modification. The proposal has great

描述（由申请人提供）：几乎一无所知，关于早期生活中关键危险因素如何影响认知功能及其后期的下降。有证据表明，导致痴呆症，尤其是阿尔茨海默氏病和血管性痴呆的神经病理学过程是在临床特征明显之前几十年开始的。最近的研究令人信服地表明，中年危险因素，尤其是与心血管疾病和生活方式因素有关的危险因素，对以后的生活认知产生了重大影响。但是，关于之前的知之甚少，例如年轻人，危险因素及其对中年及以后的认知影响的影响。我们建议通过对正在进行的CADSIA研究进行创新的辅助研究来解决这一差距。 Cardia是一项对5,115名黑白成年人的多站点前瞻性研究，在基线（1985 - 86年）中年龄18-30岁，最近完成了他们的第七次（25年）后续措施，其中测量了认知测试和大脑MRIS，并将在2015 - 16年间参加30年级的考试。我们建议在估计3100名参与者中重复和增强30年级访问的认知测试。在美国对IT类型的第一次研究中，我们建议估计关键血管，代谢和生活方式因素的30年轨迹，并通过MRI量化大脑区域的体积，以评估其成年后与认知水平和认知水平的关系。此外，我们将使用已经收集的全基因组遗传数据来研究遗传变异的关联，遗传变异已知会影响这些危险因素和大脑MRI结果，并与认知有关。科学目标的完成将有助于确定何时在中年发生认知变化，使用生活课程方法将使我们能够研究从早期生活开始的长期接触，以期研究风险因素修改的潜在影响。该提议很棒