20 YEAR CHANGES IN FITNESS & CARDIOVASCULAR DISEASE RISK

尽管有氧能力与年龄相关的下降是有据可查的，但身体活动、身体脂肪和 遗传变异对变化率的影响还不十分清楚。此外，人们对变化率如何知之甚少。 成年早期和中期的有氧能力影响心血管疾病风险因素的发展， 亚临床和临床心血管疾病（CVD）相关终点的发生率。我们建议解决这些问题 通过与20年CARDIA（冠状动脉风险发展， 青年人）考试，定于2005年6月开始举行。我们预计 约3，650名（75%）非裔美国人和白色男性的初始队列的幸存成员， 女性将返回20年的考试，在这一点上，他们将是38-50岁。拟议的总体目标 辅助研究是为了了解身体素质，身体活动，身体之间的复杂，纵向关系 质量和组成和脂肪分布，以及遗传因素及其独立或相互作用的影响， 肥胖、代谢综合征和亚临床CVD的发展。为了实现这一目标，我们建议 对所有20岁的CARDIA参与者进行测量： 有氧能力，通过限制性分级运动跑步机测试，使用与所用相同的方案 在CARDIA 0年级和7年级考试; 使用全身双能X射线吸收仪（DEXA）扫描，了解身体成分和脂肪分布; ·身体活动，使用7天的加速计记录;以及 选择的与心肺功能相关的候选基因中的DNA序列变异， 使用储存的DNA，研究代谢综合征以及对定期运动的反应。 本辅助研究的数据将与核心CARDIA检查数据相结合，以实现以下目的： 检查身体质量和成分的贡献，脂肪分布，客观测量身体活动 和特定的遗传多态性的变化，在20年的有氧能力和年龄相关的下降，有氧 从青年到中年的20年时间内，按种族和性别分层。 纵向检查有氧能力对心血管疾病危险因素变化的影响， 心血管疾病相关终点（如高血压、代谢综合征、亚临床疾病[如冠状动脉疾病]）的发生率 动脉钙]）。 这项研究的数据应该提供的信息，将有助于我们更深入地了解相互关系， 心肺适应性、身体成分和CVD相关的风险因素和终点，并可能为 我更广泛的证据为基础的建议，在心血管健康的作用健身。 地点（组织、城市、州） 凯泽基金会研究所，研究部，奥克兰，加利福尼亚州 美国亚拉巴马大学伯明翰分校 西北大学，芝加哥，IL 德克萨斯大学休斯顿健康科学学院，德克萨斯州休斯顿 明尼苏达大学，明尼苏达州明尼阿波利斯 关键人员。请参阅说明。根据需要使用续页，以下列格式提供所需信息。 从首席研究员开始。按字母顺序列出所有其他关键人员，姓在前。 名称组织在项目中的角色 Sidney，Stephen，MD研究部门首席研究员 Boerwinkle，Eric，博士德克萨斯大学遗传学中心共同研究员 Mercedes，PhD西北大学，现场中心共同研究员 雅各布斯，大卫R.，Jr，PhD明尼苏达大学，现场中心共同研究员 刘易斯，科拉，医学博士，MSPH亚拉巴马大学，现场中心联合调查员 小查尔斯·奎森伯里，生物统计学研究部博士 Sternfeld，Barbara，PhD研究部门合作研究者 威廉姆斯，O. Dale，MPH，PhD亚拉巴马大学，协调中心共同研究者 Disclo-.r#- P#_rmi_ion _t_t#_m__nt_ Annlic._ hlp. tn _仅限BIR/RTTR RP._ in.qtruc.ti（_n_ [_ Ye_ F”-I编号 PHS 398（修订版05/01）第2页_表格第2页。 主要研究者/项目负责人（最后，第一，中间）：Sidney，Stephen，MD 研究资助 目录 Pa_Numbem 首页...... 1 说明，

Although an age-related decline in aerobic capacity is well documented, the impact of physical activity, body fat, and genetic variation on the rate of change is not well understood. In addition, little is known about how rate of change in aerobic capacity during early and middle adulthood affects the development of cardiovascular disease risk factors or the incidence of subclinical and clinical cardiovascular disease (CVD) related end-points. We propose to address these issues by conducting an ancillary study in conjunction with the Year 20 CARDIA (Coronary Artery Risk Development in Young Adults) examination, which is scheduled to take place beginning in June, 2005. We anticipate that approximately 3,650 (75%) of the surviving members of the initial cohort of African American and white men and women will return for the Year 20 exam, at which point they will be 38-50 years old. The overall goal of the proposed ancillary study is to understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of obesity, the metabolic syndrome, and sub-clinical CVD. To accomplish this goal, we propose to measure, on all Year 20 CARDIA participants: ¿ Aerobic capacity, by means of a symptom-limited graded exercise treadmill test, using the same protocol as that used in CARDIA at the Year 0 and Year 7 exams; ¿ Body composition and fat distribution, using a whole body dual energy x-ray absorptiometery (DEXA) scan; ¿ Physical activity, using 7 days of accelerometer recordings; and ¿ D NA sequence variants in selected candidate genes associated with cardiorespiratory fitness, components of the metabolic syndrome, and response to regular exercise, using stored DNA. Data from this ancillary study will be combined with core CARDIA examination data to address the following aims: ¿ E xamination of the contribution of body mass and composition, fat distribution, objectively measured physical activity and specific genetic polymorphisms to the variance in Year 20 aerobic capacity and in age-related decline in aerobic capacity over a 20-year time period from young adulthood to mid-life, stratifying by race and gender. ¿ Longitudinal examination of the effect of aerobic capacity on changes in cardiovascular disease risk factors and on the incidence of CVD-related endpoints (e.g. hypertension, metabolic syndrome, subclinical disease [e.g. coronary artery calcium]). Data from this study should provide information that will help us more deeply understand the interrelationships of cardiorespiratory fitness, body composition, and CVD-related risk factors and endpoints, and may provide the basis for I more extensive evidence-based recommendations on the role of fitness in cardiovascular health. PERFORMANCESITE(S) (organization, city, state) Kaiser Foundation Research Institute, Division of Research, Oakland, CA University of Alabama, Birmingham, AL Northwestern University, Chicago, IL University of Texas, Houston Health Sciences, Houston, TX University of Minnesota, Minneapolis, MN KEY PERSONNEL. See instructions.Use continuation pages as needed to provide the required informationintheformat shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Sidney, Stephen, MD Division of Research Principal Investigator Boerwinkle, Eric, PhD University of Texas, Genetics Center Co-Investigator Carnethon, Mercedes, PhD Northwestern University, Field Center Co-Investigator Jacobs, David R., Jr, PhD University of Minnesota, Field Center Co-Investigator Lewis, Cora, MD, MSPH University of Alabama, Field Center Co-lnvestigator Quesenberry, Charles, Jr., PhD Division of Research Biostatistician Sternfeld, Barbara, PhD Division of Research Co-Investigator Williams, O. Dale, MPH, PhD University of Alabama, Coordinating Center Co-Investigator Disclo-¿.r#- P#_rmi___¿ion _t_t#_m__nt_ Annlic._hlp. tn _BIR/RTTR Only Rp._ in.qtruc.ti(_n_ [_ Ye_ F"-I No ¿ PHS 398 (Rev. 05/01) Page 2__ Form Page 2. Principal Investigator/Program Director (Last, first, middle): Sidney, Stephen, MD RESEARCH GRANT TABLE OF CONTENTS Pa_Numbem Face Page .................................................................................................................................................. 1 Description,