Mouse Models of Alcohol Induced Behavior

描述（由申请人提供）： 许多研究，第一次是在50多年前，已经证明基因在调节人类酒精中毒的发展中起着重要作用。不幸的是，在实际识别导致酗酒的基因方面只取得了有限的进展。动物模型在这方面可能有一定的用处。在科罗拉多大学以及其他地方进行的许多研究表明，基因调节许多酒精诱导的和相关的行为。我们早期的大部分工作都致力于确定基因是否影响酒精表型。特别成功的一个领域是长睡眠（LS）和短睡眠（SS）小鼠系的开发。这些品系是通过从远系杂交的异质原种（HS）小鼠开始的选择性育种而衍生的。近年来，我们一直在寻找调节睡眠时间表型的基因。已从LS和SS小鼠中开发出同源品系和重组近交品系，这将在鉴定调节睡眠时间表型的基因方面非常有用。也许更重要的是，这些小鼠已经被证明在研究许多其他酒精表型方面具有价值。我们还开发了小鼠品系（HAFT-LAFT），通过选择性育种从HS股票不同的急性功能耐受性（首次剂量耐受性）的酒精。这些老鼠是一个非常宝贵和独特的资源，必须保持。提交R24申请是为了帮助保证科罗拉多大学酒精遗传学研究的持续成功，以便我们能够继续向其他研究人员提供我们宝贵的动物。

DESCRIPTION (provided by applicant): Many studies, the first done more than 50 years ago, have demonstrated that genes play an important role in regulating the development of alcoholism in humans. Unfortunately, only limited progress has been made towards actually identifying genes that contribute to alcoholism. Animal models may be of some utility in this respect. Many studies done at the University of Colorado, as well as other places, have demonstrated that genes regulate many alcohol-induced and-related behaviors. Much of our early work was devoted to determining whether genes influence alcohol phenotypes. One area of particular success was the development of the long-sleep (LS) and short-sleep (SS) mouse lines. These lines were derived by selective breeding starting from the outbred, heterogeneous stock (HS) mice. In recent years we have been searching for the genes that regulate the sleep time phenotype. Congenic strains and recombinant inbred strains have been developed from the LS and SS mice that will be very useful in identifying genes that regulate the sleep time phenotype. Perhaps of greater importance, these mice have already proven to be of value in studying many other alcohol phenotypes. We have also developed mouse lines (HAFT-LAFT) that differ from acute functional tolerance (first dose tolerance) to alcohol, via selective breeding from the HS stock. These mice are a very valuable and unique resource that must be maintained. This R24 application is being submitted to help guarantee the continued success of alcohol genetics research at the University of Colorado and so that we can continue to supply our valuable animals to other researchers.