Research Training-Genetics of Substance Abuse

描述（由申请人提供）： 该提案正在寻求通过机构培训赠款支持一个培训方案，该方案旨在培训博士前和博士后研究员，他们将从事以研究遗传对药物滥用的影响为重点的研究事业。IBG的教师是杰出的，积极的研究和IBG的科学家们积极追求的遗传对药物滥用的影响超过35年的研究。与药物滥用有关的主要研究项目目前正在人类和动物行为遗传学方面取得进展。生物统计遗传学技术的应用和数量性状基因座方法的发展，使复杂的多基因性状调控基因的定位成为可能。从这些分析中获得的信息，沿着神经化学、神经药理学和分子遗传学研究，正被用于试图提供对与行为相关的基因功能的理解。可利用设施进行人类、小鼠和线虫模型的基因图谱研究、小鼠和线虫的行为和生化研究以及生物统计分析。 申请资助4名博士前和2名博士后学员。博士预科生获得合作学术单位的博士学位和行为遗传学证书。培训计划的学术要求包括行为遗传学，定量和生物统计遗传学，理论和基于计算机的统计学，分子遗传学，负责任的研究行为以及行为和临床表型课程的培训。额外要求根据学位授予学术单位的不同而有所不同。研究经验是培训的一个组成部分。博士后学员也追求一个正式的计划，强调个人研究以及在分子和定量行为遗传学的能力。在他们的准备其他活动包括：学生和/或技术人员的监督，研讨会演讲者的主机，客座演讲，并在一个负责任的研究行为的课程和每周杂志俱乐部的强制性出席。

DESCRIPTION (provided by applicant): This proposal is seeking support, via an institutional training grant, for a training program that is geared towards training pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 35 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical genetic techniques and the development of quantitative trait loci methods allow the mapping of genes that regulate complex polygenic traits. Information from such analyses, along with neurochemical, neuropharmacological, and molecular genetic studies, are being used in attempts to provide an understanding of gene function related to behavior. Facilities are available for gene mapping studies in human, mouse and nematode models, behavioral and biochemical studies in mice and nematodes, and biometrical analyses. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in their preparation include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, and mandatory attendance in a course on the responsible conduct of research and a weekly journal club.