Research Training-Genetics of Substance Abuse

研究培训-药物滥用遗传学

• 批准号: 7459902
• 负责人: ALLAN C COLLINS
• 金额: $ 17.15万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7459902
• 关键词: Genetic; Research Training; Substance abuse problem

DESCRIPTION (provided by applicant): This proposal is seeking support, via an institutional training grant, for a training program that is geared towards training pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBG faculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 35 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical genetic techniques and the development of quantitative trait loci methods allow the mapping of genes that regulate complex polygenic traits. Information from such analyses, along with neurochemical, neuropharmacological, and molecular genetic studies, are being used in attempts to provide an understanding of gene function related to behavior. Facilities are available for gene mapping studies in human, mouse and nematode models, behavioral and biochemical studies in mice and nematodes, and biometrical analyses. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in their preparation include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, and mandatory attendance in a course on the responsible conduct of research and a weekly journal club.

描述（由申请人提供）： 该建议是通过机构培训补助金寻求支持的培训计划的支持，该计划旨在培训培训前和博士后研究员，他们将从事研究职业，专注于研究对药物滥用遗传影响的研究。 IBG的教师在研究方面具有杰出性和积极性，IBG科学家已经积极地研究了35年以上的遗传影响对药物滥用的影响。人类和动物行为遗传学中，与药物滥用相关的主要研究项目现在正在进行中。生物遗传技术的应用和定量性状基因座方法的发展允许映射调节复杂多基因性状的基因。此类分析的信息以及神经化学，神经药物和分子遗传研究正在尝试提供对与行为相关的基因功能的尝试。设施可用于人，小鼠和线虫模型，小鼠和线虫的行为和生化研究的基因映射研究，以及生物识别分析。 要求资金支持4个占主导地位和2个博士后学员。托管前学员获得合作学术单位和行为遗传学认证的博士学位。培训计划中的学术要求包括行为遗传学，定量和生物遗传学，基于理论和计算机的统计数据，分子遗传学，负责任的研究以及行为和临床表型课程的培训。其他要求根据授予学位单位的程度而有所不同。研究经验是培训的组成部分。博士后学员还采用了一个正式的计划，该计划强调了个人研究以及分子和定量行为遗传学的能力。准备工作中的其他活动包括：对学生和/或技术人员的监督，主持研讨会演讲者的主持人，嘉宾讲课以及在负责任的研究和每周期刊俱乐部的课程中进行强制性参加。