Mouse Models of Alcohol Induced Behavior

酒精诱导行为的小鼠模型

• 批准号: 6712356
• 负责人: ALLAN C COLLINS
• 金额: $ 33.38万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6712356
• 关键词: alcoholism /alcohol abuse; behavioral genetics; disease /disorder model; gene expression; genetic models; genetic polymorphism; genetic regulation; genetically modified animals; genotype; inbreeding; laboratory mouse; model design /development; neurotransmitter receptor; phosphorylation; quantitative trait loci; substance abuse related behavior

DESCRIPTION (provided by applicant): Many studies, the first done more than 50 years ago, have demonstrated that genes play an important role in regulating the development of alcoholism in humans. Unfortunately, only limited progress has been made towards actually identifying genes that contribute to alcoholism. Animal models may be of some utility in this respect. Many studies done at the University of Colorado, as well as other places, have demonstrated that genes regulate many alcohol-induced and-related behaviors. Much of our early work was devoted to determining whether genes influence alcohol phenotypes. One area of particular success was the development of the long-sleep (LS) and short-sleep (SS) mouse lines. These lines were derived by selective breeding starting from the outbred, heterogeneous stock (HS) mice. In recent years we have been searching for the genes that regulate the sleep time phenotype. Congenic strains and recombinant inbred strains have been developed from the LS and SS mice that will be very useful in identifying genes that regulate the sleep time phenotype. Perhaps of greater importance, these mice have already proven to be of value in studying many other alcohol phenotypes. We have also developed mouse lines (HAFT-LAFT) that differ from acute functional tolerance (first dose tolerance) to alcohol, via selective breeding from the HS stock. These mice are a very valuable and unique resource that must be maintained. This R24 application is being submitted to help guarantee the continued success of alcohol genetics research at the University of Colorado and so that we can continue to supply our valuable animals to other researchers.

描述（由申请人提供）： 许多研究是50多年前完成的，它表明基因在调节人类酒精中毒的发展中起着重要作用。不幸的是，实际上仅取得了有限的进展，实际上识别出造成酒精中毒的基因。在这方面，动物模型可能具有某种用途。在科罗拉多大学以及其他地方进行的许多研究表明，基因调节了许多与酒精引起的相关行为。我们的大部分早期工作都致力于确定基因是否影响酒精表型。一个特别成功的领域是长腿（LS）和短腿（SS）小鼠系的发展。这些线是通过从近代的异质股（HS）小鼠开始的选择性繁殖来得出的。近年来，我们一直在寻找调节睡眠时间表型的基因。 LS和SS小鼠已经开发出了先天性菌株和重组近交菌株，这些菌株将在识别调节睡眠时间表型的基因方面非常有用。也许更重要的是，这些小鼠已经证明在研究许多其他酒精表型方面具有价值。我们还开发了小鼠系（haft-laft），通过从HS库存中选择性繁殖，从急性功能耐受性（首先剂量耐受）到酒精。这些老鼠是必须维护的非常有价值和独特的资源。正在提交此R24应用程序，以帮助保证科罗拉多大学酒精遗传学研究的持续成功，以便我们可以继续向其他研究人员提供宝贵的动物。