Acquisition of a 500 MHz LC-NMR

采集 500 MHz LC-NMR

• 批准号: 6876916
• 负责人: Carmelo J Rizzo
• 金额: $ 50万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2006-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876916
• 关键词: biomedical equipment purchase; biomedical equipment resource; high throughput technology; liquid chromatography; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): Purchase of a 500 MHz NMR spectrometer with a flow-injection probe and LC support for the Vanderbilt University NMR Facility is proposed. This instrument will service the research programs of five major and nine minor users from the College of Arts & Science and School of Medicine. There is a large biomedical component to the predominantly NIH-funded research programs of the investigators. The research interests include the study of drug and xenobiotic metabolism, DNA-carcinogen chemistry, lipid oxidation, peptide chemistry, neuropharmacology and drug development, the application of nanotechnology in neurotransmitter trafficking, and antibiotic biosynthesis among others. Current instrumentation no longer serves the growing needs of these research programs, and a new instrument with greater sensitivity and field dispersion is required, particularly for the two-dimensional NMR analyses such as COSY and HMBC on very small sample sizes. The LC-NMR and high-throughout sampling features of the proposed instrument will expand the research capabilities and productivity of the users. There is a strong tradition of interdisciplinary and collaborative research at Vanderbilt. The five major users are all Investigators in the NIEHS Center in Molecular Toxicology and some are affiliated with the NCI-supported Vanderbilt-lngram Cancer Center and the NIGMS-supported Center in Pharmacology and Drug Toxicology.

描述(由申请人提供)：建议为范德比尔特大学的核磁共振设施购买一台带有流动注射探头和LC支持的500 MHz核磁共振光谱仪。该仪器将为文理学院和医学院的5个主要用户和9个次要用户的研究项目提供服务。研究人员的主要由美国国立卫生研究院资助的研究项目中有一个很大的生物医学部分。研究兴趣包括药物和异体代谢、DNA致癌物质化学、脂质氧化、多肽化学、神经药理学和药物开发、纳米技术在神经递质转运中的应用以及抗生素生物合成等。目前的仪器已经不能满足这些研究项目日益增长的需求，需要一种具有更高灵敏度和场散散度的新仪器，特别是对于COSY和HMBC等非常小样品尺寸的二维核磁共振分析。拟议仪器的LC-核磁共振和高通量采样功能将扩大用户的研究能力和生产率。范德比尔特大学有着跨学科和协作研究的深厚传统。这五个主要用户都是NIEHS分子毒理学中心的研究人员，一些人隶属于NCI支持的Vanderbilt-Ingram癌症中心和NIGMS支持的药理学和药物毒理学中心。

项目成果

Enantioselective total synthesis of (+)-amabiline.

• DOI: 10.1021/ol300466a
• 发表时间: 2012-04-06
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Senter TJ;Fadeyi OO;Lindsley CW
• 通讯作者: Lindsley CW

Monolayer autoxidation of arachidonic acid to epoxyeicosatrienoic acids as a model of their potential formation in cell membranes.

• DOI: 10.1016/j.jlr.2021.100159
• 发表时间: 2022-01
• 期刊: Journal of lipid research
• 影响因子: 6.5
• 作者: Weiny JA;Boeglin WE;Calcutt MW;Stec DF;Brash AR
• 通讯作者: Brash AR

Algal Toxin Goniodomin A Binds Potassium Ion Selectively to Yield a Conformationally Altered Complex with Potential Biological Consequences.

• DOI: 10.1021/acs.jnatprod.9b01094
• 发表时间: 2020-04-24
• 期刊: JOURNAL OF NATURAL PRODUCTS
• 影响因子: 5.1
• 作者: Tainter, Craig J.;Schley, Nathan D.;Harris, Constance M.;Stec, Donald F.;Song, Anna K.;Balinski, Andrzej;May, Jody C.;McLean, John A.;Reece, Kimberly S.;Harris, Thomas M.
• 通讯作者: Harris, Thomas M.

Highly diastereoselective and general synthesis of primary β-fluoroamines.

• DOI: 10.1021/ol202415j
• 发表时间: 2011-10-21
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Schulte ML;Lindsley CW
• 通讯作者: Lindsley CW

Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs.

纤毛酰胺 A-C 的全合成：立体化学修正和天然产物引导的非天然类似物的合成。

• DOI: 10.1021/ol801842v
• 发表时间: 2008
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Lewis,JanaA;Daniels,RNathan;Lindsley,CraigW
• 通讯作者: Lindsley,CraigW