Florida Node of The Drug Abuse Clinical Trials Network

描述(由申请人提供)： 这是对NIDA的CTN的佛罗里达节点的竞争延续提议。Node的目的是制定和执行议定书，测试各种社区治疗环境中不同患者群体的治疗效果，并以一种改进Node、波多黎各和全国药物滥用治疗做法的方式传播知识。由这笔赠款资助的合作伙伴关系由迈阿密大学家庭研究中心领导，该中心拥有相当多的临床试验、多地点、艾滋病毒+、种族/民族和药物滥用治疗方面的专业知识，作为区域研究和培训中心(RRTC)。佛罗里达节点治理代表了RRTC和CTP之间的强大双向合作。这一伙伴关系的合作伙伴是佛罗里达州的五个CTP，它们是该州最大和最受尊敬的CTP之一，代表该州北部(杰克逊维尔的Gateway)、西部(坦帕/圣彼得堡的PAR)、东部(奥兰多的无毒品生活中心)和南部(迈阿密的乡村；布罗沃德县的Spectrum)部分地区。这些机构占佛罗里达州药物滥用治疗资金的45%，有能力为20,000名患者提供服务，提供异常多样化的治疗方式、患者种族和民族特征以及药物滥用和成瘾人口。该节点还包括与佛罗里达州单一州机构局长、佛罗里达州ATTC和佛罗里达州供应商协会的密切合作关系。正如我们的进度报告所显示的那样，过去4年，我们与这些伙伴的工作取得了重大成就。 此外，该提案还提出了一些辅助关系，以扩大治疗环境的多样性，包括迈阿密-戴德县的两个大型初级保健网络所代表的初级保健和社会服务环境、美沙酮治疗网络、政府经营的药物滥用治疗网络、与波多黎各和维尔京群岛ATTC的密切合作以及波多黎各的提供者网络等。 我们在过去4年中建立的基础设施使我们能够应对最初面临的挑战(例如，跨地域的沟通和协作)，并使我们能够成功实施六项CTN协议，其中包括领导一项针对药物滥用青少年的家庭治疗的大型试验(CTN-0014)，以及共同领导有史以来第一项针对西班牙语人群的药物滥用治疗多地点有效性试验(CTN-0021)。一个非常适合CTN的概念建议测试传播有效艾滋病毒干预的两种战略。

DESCRIPTION (provided by applicant): This is a competing continuation proposal for the Florida Node of NIDA's CTN. The aim of the Node is to develop and implement protocols that test the effectiveness of treatments across a broad range of community-based treatment settings with diverse patient populations, and to disseminate knowledge in a manner that improves the practice of drug abuse treatment in the Node, Puerto Rico and the nation. The partnership funded by this grant is led by the University of Miami-Center for Family Studies, with its considerable clinical trials, multi-site, HIV+, race/ethnicity, and drug abuse treatment expertise, serving as the Regional Research and Training Center (RRTC). The Florida Node governance represents strong bi-directional collaboration between the RRTC and CTPs. Collaborators in this partnership are five Florida CTPs that are among the largest and most respected in the State, representing the north (Gateway in Jacksonville), west (PAR in the Tampa/St Petersburg), East (Center for Drug Free Living in Orlando) and south (The Village in Miami; Spectrum in Broward County) parts of the State. Accounting for 45% of Florida's drug abuse treatment dollars, and with the capacity to serve 20,000 patients, these agencies offer exceptional diversity of treatment modalities, patient racial and ethnic profiles, and drug abusing and addicted populations. The Node also includes strong collaborative relationships with the Florida Single State Agency Director, the Florida ATTC, and the Florida provider association. As our progress report shows, the past 4 years have yielded major accomplishments in our work with these partners. Additionally, this proposal presents a number of ancillary relationships to expand the diversity of treatment settings, including primary care and social service settings represented by two large Miami-Dade County based primary care networks, a methadone treatment network, a government-run drug abuse treatment network, a close collaboration with the Puerto Rico and Virgin Islands ATTC, and a network of providers in Puerto Rico, among others. The infrastructure we have established over the past 4 years have allowed us to meet the challenges we had originally confronted (e.g., communication and collaboration across geographic distance) and have allowed us to successfully implement six CTN protocols including leading a large trial of family therapy for substance abusing adolescents, (CTN-0014), and co-leading the first ever multi-site effectiveness trial of drug abuse treatment with a Spanish-speaking population (CTN-0021). A concept, ideally suited for the CTN, proposes to test two strategies in the dissemination of an efficacious HIV intervention.