Regulation of RCC1 through N-terminal serine metnylation
Regulation of RCC1 through N-terminal serine metnylation
批准号:
7157893
负责人:
Christine E Schaner-Tooley
金额:
$4.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-09-01 至 2009-10-10
关键词:
HeLa cellsRNA interferencechromatinchromosome movementenzyme activitygenetic regulationguanine nucleotide exchange factorsguanosinetriphosphatasesmethylationmethyltransferasemitotic spindle apparatusmolecular assembly /self assemblymolecular geneticsneoplasm /cancer chemotherapyneoplasm /cancer geneticsnuclear transportpostdoctoral investigatorserinesubcellular fractionation
中文摘要
描述(由申请人提供):RCC1是小的ras样GTPase Ran的核苷酸交换因子。它参与许多细胞过程,包括纺锤体组装和纺锤体检查点调节,当调节不当时可导致细胞转化和致癌。确定RCC1是如何被调节的将更清楚地定义纺锤体组装和检查点调节是如何被控制的,并进一步开发针对这些过程的抗癌治疗方法。最近在Macara实验室发现了一种新的RCC1翻译后修饰,n端丝氨酸甲基化,该提议将研究其在RCC1功能调控中的作用。具体目标#1将确定RCC1功能n端丝氨酸甲基化影响的哪些方面以及它如何调节这些功能。具体目标#2将确定负责RCC1 n端丝氨酸甲基化的甲基转移酶。
英文摘要
DESCRIPTION (provided by applicant): RCC1 is the nucleotide exchange factor for the small, Ras-like GTPase Ran. It is involved in many cellular processes including spindle assembly and spindle checkpoint regulation, that when misregulated can lead to cellular transformation and carcinogenesis. Determining how RCC1 is regulated will more clearly define how spindle assembly and checkpoint regulation are controlled and further the development of anticancer therapeutics targeted against these processes. A novel post-translational modification of RCC1, N-terminal serine methylation, has recently been identified in the Macara lab, and this proposal will examine its role in the regulation of RCC1 function. Specific aim #1 will determine which aspects of RCC1 function N-terminal serine methylation affects and how it regulates these functions. Specific aim #2 will identify the methyltransferase responsible for the N-terminal serine methylation of RCC1.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Expanding the biological roles of N-terminal methylation
-
批准号:10330681
-
项目类别:
-
资助金额:$39.57万
-
财政年份:2022
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Expanding the biological roles of N-terminal methylation
-
批准号:10728366
-
项目类别:
-
资助金额:$6.58万
-
财政年份:2022
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Regulation of NRMT1 through homolog binding
-
批准号:10571563
-
项目类别:
-
资助金额:$3.84万
-
财政年份:2022
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Expanding the biological roles of N-terminal methylation
-
批准号:10543812
-
项目类别:
-
资助金额:$39.57万
-
财政年份:2022
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Deciphering the Code of N-terminal Post-translational Modification
-
批准号:9128022
-
项目类别:
-
资助金额:$1.42万
-
财政年份:2015
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Deciphering the Code of N-terminal Post-translational Modification
-
批准号:9302821
-
项目类别:
-
资助金额:$25.62万
-
财政年份:2015
-
负责人:Christine E Schaner-Tooley
-
依托单位:
The role of the first mammalian N-term. methyltransferase, NRMT, in tumorigenesis
-
批准号:8328713
-
项目类别:
-
资助金额:$8.79万
-
财政年份:2011
-
负责人:Christine E Schaner-Tooley
-
依托单位:
The role of the first mammalian N-term. methyltransferase, NRMT, in tumorigenesis
-
批准号:8714415
-
项目类别:
-
资助金额:$23.41万
-
财政年份:2011
-
负责人:Christine E Schaner-Tooley
-
依托单位:
The role of the first mammalian N-term. methyltransferase, NRMT, in tumorigenesis
-
批准号:8731642
-
项目类别:
-
资助金额:$22.7万
-
财政年份:2011
-
负责人:Christine E Schaner-Tooley
-
依托单位:
The role of the first mammalian N-term. methyltransferase, NRMT, in tumorigenesis
-
批准号:8189662
-
项目类别:
-
资助金额:$8.79万
-
财政年份:2011
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Regulation of RCC1 through N-terminal serine metnylation
-
批准号:7278264
-
项目类别:
-
资助金额:$4.88万
-
财政年份:2006
-
负责人:Christine E Schaner-Tooley
-
依托单位:
Regulation of RCC1 through N-terminal serine metnylation
-
批准号:7488369
-
项目类别:
-
资助金额:$1.07万
-
财政年份:2006
-
负责人:Christine E Schaner-Tooley
-
依托单位:
海外基金