Cross-Sensory Selective Attention

描述(由申请人提供)： 基于特征的选择性注意的神经生理学研究几乎完全集中在单一的感觉通道中。然而，在现实世界中，相关的对象往往不仅仅是在感觉上被指定的，这可能导致选择性地关注跨多个感觉系统的输入。显然，对选择性注意过程的充分理解需要在受试者注意到跨感觉系统的相关特征的条件下进行选择性注意的神经生理学研究。这一建议的主要目的是在相同的任务条件下，应用电生理记录的高时间分辨率和功能磁共振成像的精细空间分辨率，以描述与大量关于单感觉选择性注意的文献相关的跨感觉选择性注意机制的时间进程和神经解剖学基础。重要的是，这项工作将扩展到精神分裂症患者，以表征这一人群中选择性注意缺陷的神经生理学特征。我们将使用希尔亚德(1973)的选择性注意范式的变体。最终，关于跨感觉选择性注意的神经生理学的发现将提供更完整的注意过程的图景，并增加理解精神分裂症患者注意障碍的基础。

DESCRIPTION (provided by applicant): Work on the neurophysiology of feature-based selective attention has almost exclusively been focused within a single sensory modality. Yet in the real world relevant objects are often specified in more than sense, and this likely results in selectively attending to inputs across multiple sensory systems. Clearly a full understanding of selective attention processes requires that the neurophysiology of selective attention be studies under conditions in which subjects are attending to related features across sensory systems. The primary aim of this proposal is to apply the high temporal resolution of electrophysiological recordings with the fine spatial resolution of functional magnetic resonance imaging, under identical task conditions, in order to characterize both the time course and neuroanatomical substrates of cross-sensory selective attention mechanisms in relation to the vast literature on uni-sensory selective attention. Importantly, this work will be extended to schizophrenia patients, to characterize the neurophysiology of selective attention deficits in this population. A variation of the selective attention paradigm of Hillyard (1973) will be used. Ultimately, findings on the neurophysiology of cross-sensory selective attention will provide a more complete picture of attentional processes, and add to the basis for understanding attentional dysfunction in patients with schizophrenia.