Parent Supported Weight Reduction in Down Syndrome

家长支持唐氏综合症患者减重

• 批准号: 7144866
• 负责人: RICHARD K FLEMING
• 金额: $ 18.84万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7144866
• 关键词: Downs syndrome; adipose tissue; adolescence (12-20); behavior modification; behavioral /social science research tag; clinical research; comorbidity; health behavior; human subject; nutrient intake activity; nutrition education; parent offspring interaction; patient oriented research; weight gain; weight loss

DESCRIPTION (provided by applicant): Individuals with Down syndrome (DS) have mild to moderate mental retardation, short stature and associated overweight. Weight loss interventions for children and adolescents with DS have not been studied sufficiently. With typical children, interventions in which parents are taught to use behavior modification to improve dietary and activity habits have been effective. Research is needed to investigate behavioral weight reduction with a new population, adolescents with DS. This study will compare the effectiveness of: 1) a Parent Supported Weight Reduction intervention (PSWR) that combines behavior modification and nutrition/activity education (NAE), with 2) NAE alone and 3) a Wait List (WL) control group. The primary Specific Aim is to determine whether adolescents with DS in the PSWR condition lose more weight and body fat than participants in NAE alone or WL. Two secondary Specific Aims are to determine whether adolescents in PSWR are more successful than those in NAE alone in: 1) meeting the prescribed number of servings in specified food groups, and 2) increasing physical activity. Seventy-two (72) adolescents with DS between 13-18 who are overweight (body mass index > 95th percentile for age and gender), and their parents, will be randomly assigned to one of three groups: PSWR, NAE-alone or WL. PSWR and NAE-alone groups will receive a 6-month intervention, meeting weekly for 10 wks (90 min sessions), then bi-weekly and monthly. NAE components in both groups will be conducted by a nutrition educator, supervised by a nutritionist/registered dietician and a physical therapist, both with expertise in DS (co-investigators). Behavioral components of PSWR will be conducted by a behavioral psychologist with expertise in DS (the PI). Following the 6-month intervention, participants in PSWR and NAE-alone will be followed over a 6-month maintenance phase. We will measure and compare changes in body fat (BIA), BMI-z score, number of servings in specified food groups, and activity (accelerometer) at pre-intervention, 10 wks, 6 mos (post intervention) and 12 mos (maintenance). Participants in WL will not receive a concurrent intervention, but will participate in BIA and BMI-z measurement at the same intervals. WL participants will be offered the most effective intervention (PSWR or NAE) in Year 2. Our long-term goals with this project are to: 1) learn more about health promotion in families of children with DS and other developmental disabilities, and 2) develop an R01 application to investigate processes associated with long-term behavior change and health, especially adolescent-managed intervention

描述（由申请人提供）： 唐氏综合症（DS）的个体患有轻度至中度的智力低下，身材矮小且相关的超重。对患有DS的儿童和青少年的减肥干预措施尚未得到充分研究。对于典型的孩子，教导父母使用行为修改以改善饮食和活动习惯的干预措施有效。需要进行研究来研究新人，DS青少年的新人群的行为体重减轻。这项研究将比较：1）将行为修改和营养/活动教育（NAE）的父母支撑减轻干预（PSWR）与单独使用2）和3）单独的nae（WL）对照组进行比较。主要的特定目的是确定与单独使用NAE或WL的参与者相比，在PSWR状态下具有DS的青少年是否会减轻体重和体内脂肪。两个次要的特定目的是确定PSWR中的青少年是否比单独使用NAE的青少年在：1）满足规定的食品组中规定的食物数量，以及2）增加体育锻炼。 DS超重（体重指数>年龄和性别的第95个百分位数）和他们的父母将随机分配给三组之一：PSWR，NAE-OLONE或WL。 PSWR和NAE-Olone组将接受6个月的干预，每周开会10周（90分钟），然后每两周一次，每月一次。两组的NAE组件将由营养学家/注册营养师和物理治疗师监督的营养教育者进行，均在DS（共同研究人员）方面进行专业知识。 PSWR的行为成分将由具有DS（PI）专业知识的行为心理学家进行。在经过6个月的干预之后，在6个月的维护阶段将遵循PSWR和NAE-NAE-NAE-NAE-NAE-NAE-NAE-NAE-NAE。我们将测量和比较体内脂肪（BIA），BMI-Z评分，指定食物组的份量以及干预前的活动（加速度计），10周，6个MOS（干预后）和12个MO（维持）（维持）。 WL的参与者将不会同时进行干预，但会以相同的间隔参加BIA和BMI-Z测量。 WL参与者将在第二年提供最有效的干预措施（PSWR或NAE）。我们与该项目的长期目标是：1）更多有关DS和其他发育障碍儿童家庭的健康促进的信息，以及2）开发R01应用程序，以调查与长期行为变化相关的过程